8CQW
 
 | | Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B | | 分子名称: | 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | | 著者 | Kolosova, O, Zgadzay, Y, Yusupov, M. | | 登録日 | 2023-03-07 | | 公開日 | 2024-09-18 | | 最終更新日 | 2025-04-30 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Mechanism of read-through enhancement by aminoglycosides and mefloquine
Proc.Natl.Acad.Sci.USA, 2025
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1B78
 | | STRUCTURE-BASED IDENTIFICATION OF THE BIOCHEMICAL FUNCTION OF A HYPOTHETICAL PROTEIN FROM METHANOCOCCUS JANNASCHII:MJ0226 | | 分子名称: | PYROPHOSPHATASE | | 著者 | Hwang, K.Y, Chung, J.H, Han, Y.S, Kim, S.H, Cho, Y. | | 登録日 | 1999-01-27 | | 公開日 | 2000-01-28 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure-based identification of a novel NTPase from Methanococcus jannaschii.
Nat.Struct.Biol., 6, 1999
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8CQ7
 | | Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome | | 分子名称: | 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | | 著者 | Kolosova, O, Zgadzay, Y, Yusupov, M. | | 登録日 | 2023-03-03 | | 公開日 | 2024-09-11 | | 最終更新日 | 2025-04-30 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Mechanism of read-through enhancement by aminoglycosides and mefloquine
Proc.Natl.Acad.Sci.USA, 2025
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8CRE
 | | Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 | | 分子名称: | 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | | 著者 | Kolosova, O, Zgadzay, Y, Yusupov, M. | | 登録日 | 2023-03-08 | | 公開日 | 2024-09-18 | | 最終更新日 | 2025-04-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Mechanism of read-through enhancement by aminoglycosides and mefloquine
Proc.Natl.Acad.Sci.USA, 2025
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2LR1
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3CZ6
 | | Crystal Structure of the Rap1 C-terminus | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA-binding protein RAP1 | | 著者 | Feeser, E.A, Wolberger, C. | | 登録日 | 2008-04-28 | | 公開日 | 2008-05-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.
J.Mol.Biol., 380, 2008
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3CZF
 | | Crystal structure of HLA-B*2709 complexed with the glucagon receptor (GR) peptide (residues 412-420) | | 分子名称: | BETA-2-MICROGLOBULIN, GLUCAGON RECEPTOR PEPTIDE, GLYCEROL, ... | | 著者 | Loll, B, Fiorillo, M.T, Rueckert, C, Saenger, W, Sorrentino, R, Ziegler, A, Uchanska-Ziegler, B. | | 登録日 | 2008-04-29 | | 公開日 | 2009-04-07 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection.
Front Immunol, 11, 2020
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3CIQ
 | | A regulatable switch mediates self-association in an immunoglobulin fold | | 分子名称: | Beta-2-microglobulin, COPPER (II) ION, L(+)-TARTARIC ACID | | 著者 | Calabrese, M.F, Eakin, C.M, Wang, J.M, Miranker, A.D. | | 登録日 | 2008-03-11 | | 公開日 | 2008-09-02 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A regulatable switch mediates self-association in an immunoglobulin fold.
Nat.Struct.Mol.Biol., 15, 2008
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1UD7
 | | SOLUTION STRUCTURE OF THE DESIGNED HYDROPHOBIC CORE MUTANT OF UBIQUITIN, 1D7 | | 分子名称: | PROTEIN (UBIQUITIN CORE MUTANT 1D7) | | 著者 | Johnson, E.C, Lazar, G.A, Desjarlais, J.R, Handel, T.M. | | 登録日 | 1999-04-07 | | 公開日 | 1999-05-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and dynamics of a designed hydrophobic core variant of ubiquitin.
Structure Fold.Des., 7, 1999
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1U05
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3DEJ
 | | Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors | | 分子名称: | (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 | | 著者 | Wu, J, Du, J, Li, J, Ding, J. | | 登録日 | 2008-06-10 | | 公開日 | 2008-09-02 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species
J.Biol.Chem., 283, 2008
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3DGD
 | | Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 | | 分子名称: | ACETATE ION, GLYCEROL, Transthyretin, ... | | 著者 | Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. | | 登録日 | 2008-06-13 | | 公開日 | 2008-07-22 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.383 Å) | | 主引用文献 | Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition.
J.Biol.Chem., 285, 2010
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8URM
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8OEU
 | | Structure of the mammalian Pol II-SPT6 complex (composite structure, Structure 4) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Chen, Y, Kokic, G, Dienemann, C, Dybkov, O, Urlaub, H, Cramer, P. | | 登録日 | 2023-03-13 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Structure of the transcribing RNA polymerase II-Elongin complex.
Nat.Struct.Mol.Biol., 30, 2023
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8F19
 | | Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) | | 分子名称: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ... | | 著者 | Jiou, J, Chook, Y.M. | | 登録日 | 2022-11-04 | | 公開日 | 2023-07-26 | | 最終更新日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8F7A
 | | Cryo-EM structure of Importin-9 bound to RanGTP | | 分子名称: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ... | | 著者 | Bernardes, N.E, Chook, Y.M. | | 登録日 | 2022-11-18 | | 公開日 | 2023-07-26 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6ZME
 | | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | 登録日 | 2020-07-02 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
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7PZY
 | | Structure of the vacant Candida albicans 80S ribosome | | 分子名称: | 1,4-DIAMINOBUTANE, 18S ribosomal RNA, 25S ribosomal RNA, ... | | 著者 | Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | | 登録日 | 2021-10-13 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (2.32 Å) | | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
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4U50
 | | Crystal structure of Verrucarin bound to the yeast 80S ribosome | | 分子名称: | (4S,5R,10E,12Z,16R,16aS,17S,18R,19aR,23aR)-4-hydroxy-5,16a,21-trimethyl-4,5,6,7,16,16a,22,23-octahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,9,14-trione, 18S ribosomal RNA, 25S ribosomal RNA, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U4Y
 | | Crystal structure of Pactamycin bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U56
 | | Crystal structure of Blasticidin S bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U51
 | | Crystal structure of Narciclasine bound to the yeast 80S ribosome | | 分子名称: | (2S,3R,4S,4aR)-2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one, 18S ribosomal RNA, 25S ribosomal RNA, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4U4O
 | | Crystal structure of Geneticin bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | 登録日 | 2014-07-24 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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4V5D
 | | Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA. | | 分子名称: | 16S ribosomal RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | 著者 | Voorhees, R.M, Weixlbaumer, A, Loakes, D, Kelley, A.C, Ramakrishnan, V. | | 登録日 | 2009-03-24 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome.
Nat. Struct. Mol. Biol., 16, 2009
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4V67
 | | Crystal structure of a translation termination complex formed with release factor RF2. | | 分子名称: | 16S RRNA, 23S RRNA, 30S ribosomal protein S10, ... | | 著者 | Korostelev, A, Asahara, H, Lancaster, L, Laurberg, M, Hirschi, A, Noller, H.F. | | 登録日 | 2008-10-27 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of a translation termination complex formed with release factor RF2.
Proc.Natl.Acad.Sci.USA, 105, 2008
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