Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3DGD

Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6

Replaces:  3CYK
Summary for 3DGD
Entry DOI10.2210/pdb3dgd/pdb
Related1F41 1GKO 3DID
DescriptorTransthyretin, ZINC ION, ACETATE ION, ... (5 entities in total)
Functional Keywordstransthyretin, monomer, amyloidogenic intermediate, acidic ph, thyroid hormone binding protein, ligand binding protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains4
Total formula weight57083.63
Authors
Palmieri, L.C.,Freire, J.B.B.,Foguel, D.,Lima, L.M.T.R. (deposition date: 2008-06-13, release date: 2008-07-22, Last modification date: 2023-08-30)
Primary citationPalmieri, L.de.C.,Lima, L.M.,Freire, J.B.,Bleicher, L.,Polikarpov, I.,Almeida, F.C.,Foguel, D.
Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition.
J.Biol.Chem., 285:31731-31741, 2010
Cited by
PubMed: 20659897
DOI: 10.1074/jbc.M110.157206
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.383 Å)
Structure validation

218500

PDB entries from 2024-04-17

PDB statisticsPDBj update infoContact PDBjnumon