PDB: 888 件ウェブページステータス検索Chemie searchBIRD

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8GGF	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #20 of 20) 分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Papasergi-Scott, M.M, Skiniotis, G. 登録日 2023-03-08 公開日 2024-03-06 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8HDO	Structure of A2BR bound to synthetic agonists BAY 60-6583 分子名称: 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Adenosine A2b receptor, CHOLESTEROL, ... 著者 Cai, H, Xu, Y, Xu, H.E, Jiang, Y. 登録日 2022-11-05 公開日 2023-01-18 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell Discov, 8, 2022
8HDP	Structure of A2BR bound to endogenous agonists adenosine 分子名称: ADENOSINE, Adenosine A2b receptor, CHOLESTEROL, ... 著者 Cai, H, Xu, Y, Xu, H.E, Jiang, Y. 登録日 2022-11-05 公開日 2023-01-18 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell Discov, 8, 2022
8H8J	Lodoxamide-bound GPR35 in complex with G13 分子名称: 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid), CALCIUM ION, CHOLESTEROL, ... 著者 Yuan, Q, Duan, J, Liu, Q, Xu, H.E, Jiang, Y. 登録日 2022-10-23 公開日 2023-02-08 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell Discov, 8, 2022
8HMV	Structure of GPR21-Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Wong, T.S, Gao, W. 登録日 2022-12-05 公開日 2023-03-01 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Cryo-EM structure of orphan G protein-coupled receptor GPR21. MedComm (2020), 4, 2023
8HS3	Gi bound orphan GPR20 in ligand-free state 分子名称: Ggama, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Lin, X, Jiang, S, Xu, F. 登録日 2022-12-16 公開日 2023-03-08 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
8HSC	Gi bound Orphan GPR20 complex with Fab046 in ligand-free state 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Lin, X, Jiang, S, Xu, F. 登録日 2022-12-19 公開日 2023-03-08 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.22 Å) 主引用文献 The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
8HBD	Cryo-EM structure of IRL1620-bound ETBR-Gi complex 分子名称: Endothelin receptor type B,Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Yuan, Q, Ji, Y, Jiang, Y, Duan, J, Xu, H.E. 登録日 2022-10-28 公開日 2023-03-22 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
8HJ2	GPR21 wt with G15 complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X, Xu, F. 登録日 2022-11-22 公開日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8HJ0	GPR21(m5) and G15 complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X. 登録日 2022-11-22 公開日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8HIX	Cryo-EM structure of GPR21_m5_Gs 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X, Xu, F. 登録日 2022-11-22 公開日 2023-03-15 最終更新日 2023-03-22 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8HK5	C5aR1-Gi-C5a protein complex 分子名称: C5a anaphylatoxin chemotactic receptor 1, Complement C5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8HK3	C3aR-Gi-apo protein complex 分子名称: C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8HK2	C3aR-Gi-C3a protein complex 分子名称: C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8H4I	DHA-bound FFAR4 in complex with Gs 分子名称: DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Yin, H. 登録日 2022-10-10 公開日 2023-06-21 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
8H4L	DHA-bound FFAR4 in complex with Gq 分子名称: DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Yin, H. 登録日 2022-10-10 公開日 2023-06-21 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
8HMP	GPR52 with Gs and c17 分子名称: G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Chen, B, Xu, F. 登録日 2022-12-05 公開日 2023-06-21 実験手法 ELECTRON MICROSCOPY (2.77 Å) 主引用文献 Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by 19 F-NMR and cryo-electron microscopy. MedComm (2020), 4, 2023
8H4K	GW9508-bound FFAR4 in complex with Gq 分子名称: 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Yin, H. 登録日 2022-10-10 公開日 2023-06-21 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
8H0P	Structure of the NMB30-NMBR and Gq complex 分子名称: G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Li, C, Xu, Y, Liu, H, Cai, H, Xu, H.E, Yin, W. 登録日 2022-09-30 公開日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Molecular recognition of itch-associated neuropeptides by bombesin receptors Cell Res., 33, 2023
8H0Q	Structure of the GRP14-27-GRPR-Gq complex 分子名称: CHOLESTEROL, G-alpha q, GRP, ... 著者 Li, C, Xu, Y, Liu, H, Cai, H, Xu, H.E, Yin, W. 登録日 2022-09-30 公開日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Molecular recognition of itch-associated neuropeptides by bombesin receptors Cell Res., 33, 2023
8HQC	Structure of a GPCR-G protein in complex with a natural peptide agonist 分子名称: Antibody fragment, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... 著者 Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. 登録日 2022-12-13 公開日 2023-10-18 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Structure of a GPCR-G protein in complex with a synthetic peptide agonist Cell(Cambridge,Mass.), 2023
8H2G	Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Park, J.H, Ishimoto, N, Park, S.Y. 登録日 2022-10-06 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural basis for hydroxy-carboxylic acid receptor 2 activation and allosteric mechanism To Be Published
8HPT	Structure of C5a-pep bound mouse C5aR1 in complex with Go 分子名称: Antibody fragment ScFv16, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. 登録日 2022-12-13 公開日 2023-10-18 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structure of a GPCR-G protein in complex with a synthetic peptide agonist Cell(Cambridge,Mass.), 2023
8HQN	Activation mechanism of GPR132 by 9(S)-HODE 分子名称: (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-13 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8HVI	Activation mechanism of GPR132 by compound NOX-6-7 分子名称: 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-26 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023

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