PDB: 10970 件ウェブページステータス検索Chemie searchBIRD

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7AZS	70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569 分子名称: (2R,3S,4R,5R,7S,9S,10S,11R,12S,13R)-12-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2-((S)-1-(((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)-10-(((2S,3R,6R,E)-3-hydroxy-4-(methoxyimino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-7-(((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)carbamoyl)oxy)-6,14-dioxooxacyclotetradecan-4-yl 3-methylbutanoate, 16S rRNA, 23S rRNA, ... 著者 Jenner, L.B, Yusupov, M, Yusupova, G, Rak, A. 登録日 2020-11-17 公開日 2022-06-08 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186, 2023
7AZO	70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977 分子名称: (2R,3S,4R,5R,7S,9S,10S,11R,12S,13R)-12-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2-((S)-1-(((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)-10-(((2S,3R,4R,6R)-3-hydroxy-4-(methoxyamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-7-(((2-((2-nitrophenyl)sulfonamido)ethyl)carbamoyl)oxy)-6,14-dioxooxacyclotetradecan-4-yl 3-methylbutanoate, 16S rRNA, 23S rRNA, ... 著者 Jenner, L.B, Yusupov, M, Yusupova, G. 登録日 2020-11-17 公開日 2022-06-01 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186, 2023
4V9S	Crystal structure of antibiotic GE82832 bound to 70S ribosome 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... 著者 Bulkley, D.P, Brandi, L, Polikanov, Y.S, Fabbretti, A, O'Connor, M, Gualerzi, C.O, Steitz, T.A. 登録日 2013-12-05 公開日 2014-07-09 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation. Cell Rep, 6, 2014
4W2F	Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... 著者 Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V. 登録日 2014-09-12 公開日 2014-10-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56, 2014
4V8B	Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex). 分子名称: 16S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... 著者 Jenner, L, Demeshkina, N, Yusupov, M, Yusupova, G. 登録日 2011-12-06 公開日 2014-07-09 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A new understanding of the decoding principle on the ribosome. Nature, 484, 2012
4V9N	Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2. 分子名称: 16S rRNA (1504-MER), 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Santos, N, Zhu, J, Donohue, J.P, Korostelev, A.A, Noller, H.F. 登録日 2013-04-26 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal Structure of the 70S Ribosome Bound with the Q253P Mutant Form of Release Factor RF2. Structure, 21, 2013
4V6F	Elongation complex of the 70S ribosome with three tRNAs and mRNA. 分子名称: 16S ribosomal RNA, 23S RIBOSOMAL RNA, 23S RRNA, ... 著者 Jenner, L.B, Yusupova, G, Yusupov, M. 登録日 2009-07-09 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural aspects of messenger RNA reading frame maintenance by the ribosome. Nat.Struct.Mol.Biol., 17, 2010
4V6A	Structure of EF-P bound to the 70S ribosome. 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Stanley, R.E, Blaha, G. 登録日 2009-06-15 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science, 325, 2009
4V7K	Structure of RelE nuclease bound to the 70S ribosome (postcleavage state) 分子名称: 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... 著者 Neubauer, C, Gao, Y.-G, Andersen, K.R, Dunham, C.M, Kelley, A.C, Hentschel, J, Gerdes, K, Ramakrishnan, V, Brodersen, D.E. 登録日 2009-11-02 公開日 2014-07-09 最終更新日 2014-12-10 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE. Cell(Cambridge,Mass.), 139, 2009
4V83	Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome. 分子名称: 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 Zhu, J, Korostelev, A, Costantino, D, Noller, H.F, Kieft, J.S. 登録日 2010-12-13 公開日 2014-07-09 最終更新日 2014-12-10 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome. Proc.Natl.Acad.Sci.USA, 108, 2011
4V9A	Crystal Structure of the 70S ribosome with tetracycline. 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... 著者 Jenner, L, Yusupov, M, Yusupova, G. 登録日 2012-07-18 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2999 Å) 主引用文献 Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis. Proc.Natl.Acad.Sci.USA, 110, 2013
4W2G	Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... 著者 Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V. 登録日 2014-09-12 公開日 2014-10-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56, 2014
4V5K	Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... 著者 Ng, C.L, Lang, K, Meenan, N.A.G, Sharma, A, Kelley, A.C, Kleanthous, C, Ramakrishnan, V. 登録日 2010-05-29 公開日 2014-07-09 最終更新日 2019-07-31 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural Basis for 16S Ribosomal RNA Cleavage by the Cytotoxic Domain of Colicin E3. Nat.Struct.Mol.Biol., 17, 2010
4V7Z	Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin. 分子名称: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. 登録日 2010-08-18 公開日 2014-07-09 最終更新日 2021-01-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc.Natl.Acad.Sci.USA, 107, 2010
4V8F	Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin). 分子名称: 16S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... 著者 Jenner, L, Demeshkina, N, Yusupov, M, Yusupova, G. 登録日 2011-12-07 公開日 2014-07-09 最終更新日 2019-07-03 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 A new understanding of the decoding principle on the ribosome. Nature, 484, 2012
6ORD	Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Nguyen, H.A, Sunita, S, Dunham, C.M. 登録日 2019-04-30 公開日 2020-06-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Disruption of evolutionarily correlated tRNA elements impairs accurate decoding. Proc.Natl.Acad.Sci.USA, 117, 2020
6OJ2	Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Nguyen, H.A, Sunita, S, Dunham, C.M. 登録日 2019-04-10 公開日 2020-06-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Disruption of evolutionarily correlated tRNA elements impairs accurate decoding. Proc.Natl.Acad.Sci.USA, 117, 2020
6OSI	Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate) 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Hoffer, E.D, Subaramanian, S, Hong, S, Maehigashi, T, Dunham, C.M. 登録日 2019-05-01 公開日 2020-10-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (4.14 Å) 主引用文献 Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing. Elife, 9, 2020
6OF1	Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Khabibullina, N.F, Tereshchenkov, A.G, Komarova, E.S, Syroegin, E.A, Shiriaev, D.I, Paleskava, A, Kartsev, V.G, Bogdanov, A.A, Konevega, A.L, Dontsova, O.A, Sergiev, P.V, Osterman, I.A, Polikanov, Y.S. 登録日 2019-03-28 公開日 2019-04-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides. Antimicrob.Agents Chemother., 63, 2019
6OXI	Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA) 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Pavelich, I.J, Hoffer, E.D, Maehigashi, T, Dunham, C.M. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.495 Å) 主引用文献 Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability. Nucleic Acids Res., 47, 2019
6OXA	Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU) 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Pavelich, I.J, Hoffer, E.D, Maehigashi, T, Dunham, C.M. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability. Nucleic Acids Res., 47, 2019
7RQ8	Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Mitcheltree, M.J, Pisipati, A, Syroegin, E.A, Silvestre, K.J, Klepacki, D, Mason, J.D, Terwilliger, D.W, Testolin, G, Pote, A.R, Wu, K.J.Y, Ladley, R.P, Chatman, K, Mankin, A.S, Polikanov, Y.S, Myers, A.G. 登録日 2021-08-06 公開日 2021-10-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature, 599, 2021
7RQD	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. 登録日 2021-08-06 公開日 2022-01-26 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat.Struct.Mol.Biol., 29, 2022
7RQE	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. 登録日 2021-08-06 公開日 2022-01-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat.Struct.Mol.Biol., 29, 2022
7RQA	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, ... 著者 Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. 登録日 2021-08-06 公開日 2022-01-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat.Struct.Mol.Biol., 29, 2022

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