6OF1
Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution
This is a non-PDB format compatible entry.
Summary for 6OF1
Entry DOI | 10.2210/pdb6of1/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total) |
Functional Keywords | dirithromycin, macrolide, antibiotic, 70s ribosome, inhibitor, nascent peptide exit tunnel, ribosomal protein ul4, ribosome |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4573555.65 |
Authors | Khabibullina, N.F.,Tereshchenkov, A.G.,Komarova, E.S.,Syroegin, E.A.,Shiriaev, D.I.,Paleskava, A.,Kartsev, V.G.,Bogdanov, A.A.,Konevega, A.L.,Dontsova, O.A.,Sergiev, P.V.,Osterman, I.A.,Polikanov, Y.S. (deposition date: 2019-03-28, release date: 2019-04-17, Last modification date: 2023-11-15) |
Primary citation | Khabibullina, N.F.,Tereshchenkov, A.G.,Komarova, E.S.,Syroegin, E.A.,Shiriaev, D.I.,Paleskava, A.,Kartsev, V.G.,Bogdanov, A.A.,Konevega, A.L.,Dontsova, O.A.,Sergiev, P.V.,Osterman, I.A.,Polikanov, Y.S. Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides. Antimicrob.Agents Chemother., 63:-, 2019 Cited by PubMed: 30936109DOI: 10.1128/AAC.02266-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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