PDB: 19228 件ウェブページステータス検索Chemie searchBIRD

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7AC7	Structure of accomodated trans-translation complex on E. Coli stalled ribosome. 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. 登録日 2020-09-10 公開日 2021-08-18 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
4Y93	Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk) 分子名称: 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide, CALCIUM ION, Non-specific protein-tyrosine kinase,Non-specific protein-tyrosine kinase, ... 著者 Wang, Q, Kuriyan, J. 登録日 2015-02-16 公開日 2015-03-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.695 Å) 主引用文献 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
7YF5	Crystal Structure of the UDPGA Binding Domain of the Human Phase II Metabolizing Enzyme UDP-Glucuronosyltransferase 2B10 分子名称: SULFATE ION, UDP-glucuronosyltransferase 2B10 著者 Yin, X.L, Tong, J.S. 登録日 2022-07-07 公開日 2023-07-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.527 Å) 主引用文献 Crystal Structure Determination of Nucleotide-sugar Binding Domain of Human UDP-glucuronosyltransferases 2B10. Protein Pept.Lett., 30, 2023
7A8R	Structure of RecQL from Bos taurus 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase, MAGNESIUM ION, ... 著者 Rety, S, Chen, W.F, Xi, X.G. 登録日 2020-08-30 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Endogenous Bos taurus RECQL is predominantly monomeric and more active than oligomers. Cell Rep, 36, 2021
6MOH	Dimeric DARPin C_R3 complex with EpoR 分子名称: Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... 著者 Jude, K.M, Mohan, K, Garcia, K.C. 登録日 2018-10-04 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
6MTU	Crystal structure of human Scribble PDZ1:pMCC complex 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Colorectal mutant cancer protein, ... 著者 Caria, S, Stewart, B.Z, Humbert, P.O, Kvansakul, M. 登録日 2018-10-22 公開日 2019-08-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.141 Å) 主引用文献 Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains. Febs J., 286, 2019
6N1G	Crystal structure of Aquaglyceroporin AQP7 分子名称: Aquaporin-7, GLYCEROL 著者 Vahedi-Faridi, A, Lodowski, D, Kowatz, T. 登録日 2018-11-08 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.995 Å) 主引用文献 Aquaporin-7: A Dynamic Aquaglyceroporin With Greater Water and Glycerol Permeability Than Its Bacterial Homolog GlpF. Front Physiol, 11, 2020
7AUD	Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Bloom syndrome protein,Bloom syndrome protein, DNA (5'-D(*GP*TP*AP*CP*CP*CP*GP*AP*TP*GP*TP*GP*T)-3'), ... 著者 Chen, X, Oliver, A.W. 登録日 2020-11-02 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Elife, 10, 2021
4YXS	CAMP-DEPENDENT PROTEIN KINASE PKA CATALYTIC SUBUNIT WITH PKI-5-24 分子名称: N-BENZYL-9H-PURIN-6-AMINE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Schiffer, A, Wendt, K.U. 登録日 2015-03-23 公開日 2015-05-20 最終更新日 2015-06-03 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles. Angew.Chem.Int.Ed.Engl., 54, 2015
7AJU	Cryo-EM structure of the 90S-exosome super-complex (state Post-A1-exosome) 分子名称: 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... 著者 Cheng, J, Lau, B, Flemming, D, Venuta, G.L, Berninghausen, O, Beckmann, R, Hurt, E. 登録日 2020-09-29 公開日 2020-12-30 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome. Mol.Cell, 81, 2021
7AJT	Cryo-EM structure of the 90S-exosome super-complex (state Pre-A1-exosome) 分子名称: 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... 著者 Cheng, J, Lau, B, Flemming, D, Venuta, G.L, Berninghausen, O, Beckmann, R, Hurt, E. 登録日 2020-09-29 公開日 2020-12-30 最終更新日 2021-02-03 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome. Mol.Cell, 81, 2021
4Z84	PKAB3 in complex with pyrrolidine inhibitor 34a 分子名称: 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, METHANOL, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Lund, B.A, Alam, K.A, Engh, R.A. 登録日 2015-04-08 公開日 2015-12-02 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.554 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic. Chemistry, 22, 2016
6N8S	Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). aPKC phosphorylated, crystal form 3. 分子名称: Lethal(2) giant larvae protein homolog 2 著者 Almagor, L, Weis, W.I. 登録日 2018-11-30 公開日 2019-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2. Proc.Natl.Acad.Sci.USA, 116, 2019
7AUC	Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Chen, X, Oliver, A.W. 登録日 2020-11-02 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Elife, 10, 2021
6MTV	Crystal structure of human Scribble PDZ1:MCC complex 分子名称: Colorectal mutant cancer protein, DI(HYDROXYETHYL)ETHER, Protein scribble homolog, ... 著者 Caria, S, Stewart, B.Z, Humbert, P.O, Kvansakul, M. 登録日 2018-10-22 公開日 2019-08-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.597 Å) 主引用文献 Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains. Febs J., 286, 2019
4YXR	CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH inhibitor. 分子名称: 3-methyl-2H-indazole, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Schiffer, A, Wendt, K.U. 登録日 2015-03-23 公開日 2015-05-27 最終更新日 2015-06-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles. Angew.Chem.Int.Ed.Engl., 54, 2015
4Z81	Crystal structure of AMA4 DI-DII-EGF1 from Toxoplasma gondii 分子名称: EGF family domain-containing protein, GLYCEROL 著者 Parker, M.L, Boulanger, M.J. 登録日 2015-04-08 公開日 2015-12-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair. Proc.Natl.Acad.Sci.USA, 113, 2016
7ANW	hSARM1 NAD+ complex 分子名称: NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Mim, C, Isupov, M.N, Zalk, R, Dessau, M, Hons, M, Opatowsky, Y. 登録日 2020-10-13 公開日 2020-11-11 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 Structural basis for SARM1 inhibition and activation under energetic stress. Elife, 9, 2020
6MZ2	CTX-M-14 Class A Beta-Lactamase in Complex with Avibactam at pH 7.9 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, PHOSPHATE ION, ... 著者 Pemberton, O.A, Chen, Y. 登録日 2018-11-03 公開日 2019-11-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (0.83 Å) 主引用文献 Mechanism of proton transfer in class A beta-lactamase catalysis and inhibition by avibactam. Proc.Natl.Acad.Sci.USA, 117, 2020
6N2V	Manganese riboswitch from Xanthmonas oryzae bound to Mn(II) 分子名称: MAGNESIUM ION, MANGANESE (II) ION, SODIUM ION, ... 著者 Price, I.R, Ke, A. 登録日 2018-11-14 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Local-to-global signal transduction at the core of a Mn2+sensing riboswitch. Nat Commun, 10, 2019
6N3J	MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag 分子名称: CTD-SP1 fragment of HIV-1 Gag 著者 Purdy, M.D, Shi, D, Hattne, J, Chrustowicz, J. 登録日 2018-11-15 公開日 2018-12-12 最終更新日 2023-10-11 実験手法 ELECTRON CRYSTALLOGRAPHY (3 Å) 主引用文献 MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4Z6A	Crystal Structure of a FVIIa-Trypsin Chimera (YT) in Complex with Soluble Tissue Factor 分子名称: CALCIUM ION, CITRIC ACID, Coagulation factor VII, ... 著者 Sorensen, A.B, Svensson, L.A, Gandhi, P.S. 登録日 2015-04-04 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity. J.Biol.Chem., 291, 2016
5QC4	Crystal structure of human Cathepsin-S with bound ligand 分子名称: 2-[5-[5-ethanoyl-1-[(2~{R})-2-oxidanyl-3-[4-(2-oxidanylpropan-2-yl)piperidin-1-yl]propyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-yl-ethanone, Cathepsin S 著者 Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. 登録日 2017-08-04 公開日 2017-12-20 最終更新日 2021-11-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
4Z83	PKAB3 in complex with pyrrolidine inhibitor 47a 分子名称: 7-{(3S,4R)-4-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}quinazolin-4(3H)-one, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Lund, B.A, Alam, K.A, Engh, R.A. 登録日 2015-04-08 公開日 2015-12-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic. Chemistry, 22, 2016
6MZ1	CTX-M-14 Class A Beta-Lactamase in Complex with Avibactam at pH 5.3 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, PHOSPHATE ION, ... 著者 Pemberton, O.A, Chen, Y. 登録日 2018-11-03 公開日 2019-11-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Mechanism of proton transfer in class A beta-lactamase catalysis and inhibition by avibactam. Proc.Natl.Acad.Sci.USA, 117, 2020

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