4YXR

CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH inhibitor.

Summary for 4YXR

DescriptorcAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 3-methyl-2H-indazole, ... (4 entities in total)
Functional Keywordscomplex (phosphotransferase-inhibitor) complex, transferase
Biological sourceBos taurus (Bovine)
Cellular locationCytoplasm  P00517
Total number of polymer chains2
Total molecular weight43065.98
Authors
Schiffer, A.,Wendt, K.U. (deposition date: 2015-03-23, release date: 2015-05-27, Last modification date: 2015-06-03)
Primary citation
Pilger, J.,Mazur, A.,Monecke, P.,Schreuder, H.,Elshorst, B.,Bartoschek, S.,Langer, T.,Schiffer, A.,Krimm, I.,Wegstroth, M.,Lee, D.,Hessler, G.,Wendt, K.U.,Becker, S.,Griesinger, C.
A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.
Angew.Chem.Int.Ed.Engl., 54:6511-6515, 2015
PubMed: 25877959 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201500671
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.194605.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution