PDB: 46984 件ウェブページステータス検索Chemie searchBIRD

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3HHS	Crystal Structure of Manduca sexta prophenoloxidase 分子名称: COPPER (II) ION, Phenoloxidase subunit 1, Phenoloxidase subunit 2 著者 Li, Y, Wang, Y, Jiang, H, Deng, J. 登録日 2009-05-17 公開日 2009-09-29 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes. Proc.Natl.Acad.Sci.USA, 106, 2009
4ZTH	Structure of human p38aMAPK-arylpyridazinylpyridine fragment complex used in inhibitor discovery 分子名称: 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-chloro-3-phenyl-4-(pyridin-4-yl)pyridazine, BETA-MERCAPTOETHANOL, ... 著者 Grum-Tokars, V.L, Roy, S.M, Watterson, D.M. 登録日 2015-05-14 公開日 2016-06-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A Selective and Brain Penetrant p38 alpha MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction. J.Med.Chem., 62, 2019
4XRZ	Human Cytochrome P450 2D6 BACE1 Inhibitor 6 Complex 分子名称: (4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine, Cytochrome P450 2D6, GLYCEROL, ... 著者 Johnson, E.F, Fan, Y. 登録日 2015-01-21 公開日 2015-05-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors. J.Med.Chem., 58, 2015
5ARI	Bovine mitochondrial ATP synthase state 2b 分子名称: ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL, ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, ... 著者 Zhou, A, Rohou, A, Schep, D.G, Bason, J.V, Montgomery, M.G, Walker, J.E, Grigorieff, N, Rubinstein, J.L. 登録日 2015-09-24 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (7.4 Å) 主引用文献 Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife, 4, 2015
6B82	Zebra Fish CYP-450 17A1 Mutant Abiraterone Complex 分子名称: ACETATE ION, Abiraterone, CHLORIDE ION, ... 著者 Pallan, P.S, Egli, M. 登録日 2017-10-05 公開日 2017-12-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Inherent steroid 17 alpha ,20-lyase activity in defunct cytochrome P450 17A enzymes. J. Biol. Chem., 293, 2018
5ARE	Bovine mitochondrial ATP synthase state 1b 分子名称: ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL, ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, ... 著者 Zhou, A, Rohou, A, Schep, D.G, Bason, J.V, Montgomery, M.G, Walker, J.E, Grigorieff, N, Rubinstein, J.L. 登録日 2015-09-24 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife, 4, 2015
3NCL	Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor 分子名称: FORMIC ACID, Suppressor of tumorigenicity 14 protein, phenyl (4-carbamimidoylbenzyl)phosphonate 著者 Ray, M, Brown, C, Egea, P. 登録日 2010-06-04 公開日 2011-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Peptide length and leaving-group sterics influence potency of Peptide phosphonate protease inhibitors. Chem.Biol., 18, 2011
3IZZ	Models for ribosome components that are nearest neighbors to the bovine mitochondrial initiation factor2 bound to the E. Coli ribosome 分子名称: Helix 18 (Small Subunit), Helix 44 (Small Subunit), Helix 5, ... 著者 Yassin, A.S, Haque, E, Datta, P.P, Elmore, K, Banavali, N.K, Spremulli, L.L, Agrawal, R.K. 登録日 2011-01-20 公開日 2011-03-30 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (10.8 Å) 主引用文献 Insertion domain within mammalian mitochondrial translation initiation factor 2 serves the role of eubacterial initiation factor 1. Proc.Natl.Acad.Sci.USA, 108, 2011
3J0J	Fitted atomic models of Thermus thermophilus V-ATPase subunits into cryo-EM map 分子名称: ADENOSINE-5'-DIPHOSPHATE, V-type ATP synthase alpha chain, V-type ATP synthase beta chain, ... 著者 Lau, W.C.Y, Rubinstein, J.L. 登録日 2011-08-24 公開日 2011-12-14 最終更新日 2018-07-18 実験手法 ELECTRON MICROSCOPY (9.7 Å) 主引用文献 Subnanometre-resolution structure of the intact Thermus thermophilus H+-driven ATP synthase. Nature, 481, 2012
3JAS	Cryo-EM structure of dynamic GDP-microtubule (14 protofilaments) decorated with kinesin 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Zhang, R, Nogales, E. 登録日 2015-06-19 公開日 2015-08-12 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins. Cell(Cambridge,Mass.), 162, 2015
3JAT	Cryo-EM structure of GMPCPP-microtubule (14 protofilaments) decorated with kinesin 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... 著者 Zhang, R, Nogales, E. 登録日 2015-06-20 公開日 2015-08-12 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins. Cell(Cambridge,Mass.), 162, 2015
6N61	Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Capistruin 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Capistruin, ... 著者 Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. 登録日 2018-11-24 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.253 Å) 主引用文献 Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6MJB	Structure of Candida glabrata Csm1:Dsn1(14-72) complex 分子名称: Kinetochore-associated protein DSN1, Monopolin complex subunit CSM1 著者 Singh, N, Corbett, K.D. 登録日 2018-09-20 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 The molecular basis of monopolin recruitment to the kinetochore. Chromosoma, 128, 2019
6CG2	Crystal Structure of KDM4A with Compound 8 分子名称: 2-[5-(3-hydroxyphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acid, Lysine-specific demethylase 4A, NICKEL (II) ION, ... 著者 Hosfield, D.J, Nie, Z. 登録日 2018-02-19 公開日 2018-04-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structure-based design and discovery of potent and selective KDM5 inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
8F2K	Structure of yeast F1-ATPase determined with 100 micromolar cruentaren A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP synthase subunit alpha, ATP synthase subunit beta, ... 著者 Guo, H, Rubinstein, J.L. 登録日 2022-11-08 公開日 2023-04-05 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 CryoEM Structure with ATP Synthase Enables Late-Stage Diversification of Cruentaren A. Chemistry, 29, 2023
3UA5	Crystal Structure of P450 2B6 (Y226H/K262R) in complex with two molecules of Amlodipine 分子名称: Amlodipine, Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE 著者 Shah, M.B, Stout, C.D, Halpert, J.R. 登録日 2011-10-21 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules. Biochemistry, 51, 2012
4OVP	CRYSTAL STRUCTURE OF A TRAP PERIPLASMIC SOLUTE BINDING PROTEIN FROM SULFITOBACTER sp. NAS-14.1, TARGET EFI-510292, WITH BOUND ALPHA-D-MANURONATE 分子名称: C4-dicarboxylate transport system substrate-binding protein, alpha-D-mannopyranuronic acid 著者 Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2013-12-11 公開日 2014-01-08 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes. Biochemistry, 54, 2015
6N60	Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Microcin J25 (MccJ25) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. 登録日 2018-11-23 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.68 Å) 主引用文献 Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
3TDA	Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6 分子名称: Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Prinomastat, ... 著者 Wang, A, Stout, C.D, Johnson, E.F. 登録日 2011-08-10 公開日 2012-08-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290, 2015
4OBJ	Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (S451N) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, GLYCEROL, ... 著者 Kolli, M. 登録日 2014-01-07 公開日 2014-11-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 HIV-1 protease-substrate coevolution in nelfinavir resistance. J.Virol., 88, 2014
4OBD	Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate variant (L449F/S451N) 分子名称: 1,2-ETHANEDIOL, GLYCEROL, HIV-1 Protease, ... 著者 Kolli, M. 登録日 2014-01-07 公開日 2014-11-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 HIV-1 protease-substrate coevolution in nelfinavir resistance. J.Virol., 88, 2014
4OBK	Crystal structure of inactive HIV-1 protease in complex with the P1-P6 substrate variant (L449F/S451N) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, GLYCEROL, ... 著者 Kolli, M. 登録日 2014-01-07 公開日 2014-11-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 HIV-1 protease-substrate coevolution in nelfinavir resistance. J.Virol., 88, 2014
2WSS	The structure of the membrane extrinsic region of bovine ATP synthase 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL, ... 著者 Rees, D.M, Leslie, A.G.W, Walker, J.E. 登録日 2009-09-09 公開日 2009-11-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The Structure of the Membrane Extrinsic Region of Bovine ATP Synthase Proc.Natl.Acad.Sci.USA, 106, 2009
4P1B	CRYSTAL STRUCTURE OF THE TOLUENE 4-MONOOXYGENASE HYDROXYLASE-FERREDOXIN C7S E16C C84A C85A VARIANT ELECTRON-TRANSFER COMPLEX 分子名称: ACETATE ION, DI(HYDROXYETHYL)ETHER, FE (III) ION, ... 著者 Acheson, J.F, Fox, B.G. 登録日 2014-02-25 公開日 2014-10-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system. Nat Commun, 5, 2014
6NE0	Structure of double-stranded target DNA engaged Csy complex from Pseudomonas aeruginosa (PA-14) 分子名称: CRISPR RNA (60-MER), CRISPR target DNA (44-MER), CRISPR-associated endonuclease Cas6/Csy4, ... 著者 Chowdhury, S, Rollins, M.F, Carter, J, Golden, S.M, Miettinen, H.M, Santiago-Frangos, A, Faith, D, Lawrence, M.C, Wiedenheft, B, Lander, G.C. 登録日 2018-12-15 公開日 2018-12-26 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry. Mol. Cell, 74, 2019

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