3UA5
Crystal Structure of P450 2B6 (Y226H/K262R) in complex with two molecules of Amlodipine
Summary for 3UA5
Entry DOI | 10.2210/pdb3ua5/pdb |
Related | 3IBD 3QOA 3QU8 |
Descriptor | Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, Amlodipine, ... (4 entities in total) |
Functional Keywords | p450, human cytochrome p450 2b6, monooxygenase, oxidoreductase, membrane protein, cyp 2b6 |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P20813 |
Total number of polymer chains | 2 |
Total formula weight | 112160.49 |
Authors | Shah, M.B.,Stout, C.D.,Halpert, J.R. (deposition date: 2011-10-21, release date: 2012-09-12, Last modification date: 2023-09-13) |
Primary citation | Shah, M.B.,Wilderman, P.R.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules. Biochemistry, 51:7225-7238, 2012 Cited by PubMed: 22909231DOI: 10.1021/bi300894z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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