3UA5

Crystal Structure of P450 2B6 (Y226H/K262R) in complex with two molecules of Amlodipine

Summary for 3UA5

Entry DOI	10.2210/pdb3ua5/pdb
Related	3IBD 3QOA 3QU8
Descriptor	Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, Amlodipine, ... (4 entities in total)
Functional Keywords	p450, human cytochrome p450 2b6, monooxygenase, oxidoreductase, membrane protein, cyp 2b6
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P20813
Total number of polymer chains	2
Total formula weight	112160.49
Authors	Shah, M.B.,Stout, C.D.,Halpert, J.R. (deposition date: 2011-10-21, release date: 2012-09-12, Last modification date: 2023-09-13)
Primary citation	Shah, M.B.,Wilderman, P.R.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules. Biochemistry, 51:7225-7238, 2012 Cited by PubMed: 22909231 DOI: 10.1021/bi300894z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation