6B82

Zebra Fish CYP-450 17A1 Mutant Abiraterone Complex

Summary for 6B82

Entry DOI	10.2210/pdb6b82/pdb
Descriptor	Cytochrome P450, family 17, subfamily A, polypeptide 1, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone, ... (6 entities in total)
Functional Keywords	cytochrome p450, cyp17a1 mutant, p450 17a1, monooxygenase, 17a-hydroxylase, heme protein, cytochrome p450 oxidoreductase, abiraterone, 17a-hydroxylation, membrane, microsome, endoplasmic reticulum, oxidoreductase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	2
Total formula weight	117146.05
Authors	Pallan, P.S.,Egli, M. (deposition date: 2017-10-05, release date: 2017-12-13, Last modification date: 2023-10-04)
Primary citation	Gonzalez, E.,Johnson, K.M.,Pallan, P.S.,Phan, T.T.N.,Zhang, W.,Lei, L.,Wawrzak, Z.,Yoshimoto, F.K.,Egli, M.,Guengerich, F.P. Inherent steroid 17 alpha ,20-lyase activity in defunct cytochrome P450 17A enzymes. J. Biol. Chem., 293:541-556, 2018 Cited by PubMed: 29212707 DOI: 10.1074/jbc.RA117.000504 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.03 Å)

Structure validation