6B82
Zebra Fish CYP-450 17A1 Mutant Abiraterone Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004508 | molecular_function | steroid 17-alpha-monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006694 | biological_process | steroid biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0016829 | molecular_function | lyase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0030237 | biological_process | female sex determination |
| A | 0030238 | biological_process | male sex determination |
| A | 0042446 | biological_process | hormone biosynthetic process |
| A | 0042448 | biological_process | progesterone metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047006 | molecular_function | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity |
| A | 1903449 | biological_process | androst-4-ene-3,17-dione biosynthetic process |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004508 | molecular_function | steroid 17-alpha-monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0006694 | biological_process | steroid biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0016829 | molecular_function | lyase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0030237 | biological_process | female sex determination |
| B | 0030238 | biological_process | male sex determination |
| B | 0042446 | biological_process | hormone biosynthetic process |
| B | 0042448 | biological_process | progesterone metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047006 | molecular_function | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity |
| B | 1903449 | biological_process | androst-4-ene-3,17-dione biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue HEM A 601 |
| Chain | Residue |
| A | ARG109 |
| A | THR321 |
| A | VAL377 |
| A | LEU381 |
| A | HIS384 |
| A | PRO445 |
| A | PHE446 |
| A | ARG451 |
| A | CYS453 |
| A | LEU454 |
| A | ALA459 |
| A | ILE125 |
| A | AER602 |
| A | ALA126 |
| A | TRP134 |
| A | ARG138 |
| A | ILE310 |
| A | ALA313 |
| A | THR317 |
| A | THR318 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue AER A 602 |
| Chain | Residue |
| A | SER215 |
| A | ILE218 |
| A | VAL219 |
| A | GLU309 |
| A | THR317 |
| A | VAL377 |
| A | SER378 |
| A | HEM601 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 603 |
| Chain | Residue |
| A | PHE197 |
| A | TYR201 |
| A | TYR214 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for residue HEM B 601 |
| Chain | Residue |
| B | ARG109 |
| B | ILE125 |
| B | ALA126 |
| B | TRP134 |
| B | ARG138 |
| B | ILE310 |
| B | ALA313 |
| B | THR317 |
| B | THR318 |
| B | VAL377 |
| B | HIS384 |
| B | PRO445 |
| B | PHE446 |
| B | GLY447 |
| B | ARG451 |
| B | CYS453 |
| B | LEU454 |
| B | GLY455 |
| B | ALA459 |
| B | AER602 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue AER B 602 |
| Chain | Residue |
| B | SER215 |
| B | GLU309 |
| B | THR317 |
| B | VAL493 |
| B | HEM601 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 603 |
| Chain | Residue |
| B | ARG358 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue ACT B 604 |
| Chain | Residue |
| B | LYS72 |
| B | TYR73 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 605 |
| Chain | Residue |
| B | PHE197 |
| B | TYR201 |
| B | TYR214 |
| B | LEU255 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 606 |
| Chain | Residue |
| A | PRO238 |
| B | MET81 |
| B | ASP225 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGVRVCLG |
| Chain | Residue | Details |
| A | PHE446-GLY455 |
