6VHJ
 
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6VLJ
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6VYN
 | | N-terminal domain of mouse surfactant protein B with bound lipid, wild type | | 分子名称: | (7Z,19R,22R)-25-amino-22-hydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphapentacos-7-en-19-yl (9Z)-octadec-9-enoate, Pulmonary surfactant-associated protein B | | 著者 | Rapoport, T.A, Bodnar, N.O. | | 登録日 | 2020-02-27 | | 公開日 | 2020-11-25 | | 最終更新日 | 2021-01-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
Mol.Cell, 81, 2021
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8CGP
 | | Insulin regulated aminopeptidase (IRAP) in complex with an allosteric aryl sulfonamide inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Mpakali, A, Stratikos, E, Giastas, P. | | 登録日 | 2023-02-06 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase.
J.Mol.Biol., 436, 2024
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6RFP
 | | ERK2 MAP kinase with mutations at Helix-G | | 分子名称: | Mitogen-activated protein kinase 1 | | 著者 | Livnah, O, Eitan-Wexler, M. | | 登録日 | 2019-04-16 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop.
J.Biol.Chem., 295, 2020
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4FQS
 | | Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Thymidylate synthase | | 著者 | Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C. | | 登録日 | 2012-06-25 | | 公開日 | 2013-08-07 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: insights into the selectivity and mode of inhibition
To be Published
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4FOG
 | | Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid | | 分子名称: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Thymidylate synthase | | 著者 | Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2012-06-20 | | 公開日 | 2013-08-07 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition
To be Published
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4FOX
 | | Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | | 著者 | Reddy, M.C.M, Bruning, J.B, Sacchettini, J.C, Harshbarger, W, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2012-06-21 | | 公開日 | 2013-08-07 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition
To be Published
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6VJQ
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6FC2
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4GXK
 | | R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dATP analog | | 分子名称: | 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | | 登録日 | 2012-09-04 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | | 主引用文献 | DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion.
Nucleic Acids Res., 41, 2013
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4GXJ
 | | R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dCTP analog | | 分子名称: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | | 登録日 | 2012-09-04 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion.
Nucleic Acids Res., 41, 2013
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4FOA
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1YRN
 | | CRYSTAL STRUCTURE OF THE MATA1/MATALPHA2 HOMEODOMAIN HETERODIMER BOUND TO DNA | | 分子名称: | DNA (5'-D(*TP*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*TP*AP*TP*TP*AP*C P*AP*TP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*AP*TP*GP*TP*AP*AP*TP*AP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT A1 HOMEODOMAIN), ... | | 著者 | Li, T, Stark, M.R, Johnson, A.D, Wolberger, C. | | 登録日 | 1995-11-02 | | 公開日 | 1996-01-29 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA.
Science, 270, 1995
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7VW3
 | | Cryo-EM structure of SaCas9-sgRNA-DNA ternary complex | | 分子名称: | CRISPR-associated endonuclease Cas9, MAGNESIUM ION, Non-target DNA strand, ... | | 著者 | Du, W.H, Qian, J.Q, Huang, Q. | | 登録日 | 2021-11-09 | | 公開日 | 2023-03-15 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Full-Length Model of SaCas9-sgRNA-DNA Complex in Cleavage State.
Int J Mol Sci, 24, 2023
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5ERA
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3NJ0
 | | X-ray crystal structure of the PYL2-pyrabactin A complex | | 分子名称: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL2, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Peterson, F.C, Burgie, E.S, Bingman, C.A, Volkman, B.F, Phillips Jr, G.N, Cutler, S.R, Jensen, D.R, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2010-06-16 | | 公開日 | 2010-08-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structural basis for selective activation of ABA receptors.
Nat.Struct.Mol.Biol., 17, 2010
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3N5F
 | | Crystal Structure of L-N-carbamoylase from Geobacillus stearothermophilus CECT43 | | 分子名称: | CACODYLATE ION, COBALT (II) ION, ISOPROPYL ALCOHOL, ... | | 著者 | Garcia-Pino, A, Martinez-Rodriguez, S, Gavira, J.A. | | 登録日 | 2010-05-25 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Mutational and structural analysis of L-N-carbamoylase reveals new insights into a peptidase m20/m25/m40 family member.
J.Bacteriol., 194, 2012
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4CVA
 | | MPS1 kinase with 3-aminopyridin-2-one inhibitors | | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, DUAL SPECIFICITY PROTEIN KINASE TTK, ... | | 著者 | Fearon, D, Bavetsias, V, Bayliss, R, Schmitt, J, Westwood, I.M, vanMontfort, R.L.M, Jones, K. | | 登録日 | 2014-03-24 | | 公開日 | 2015-04-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Protein Kinase Selectivity of a 3-Aminopyridin-2- One Based Fragment Library, Identification of 3-Amino-5-(Pyridin-4-Yl)Pyridin-2(1H)-One as a Novel Scaffold for Mps1 Inhibition
To be Published
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5ER7
 | | Connexin-26 Bound to Calcium | | 分子名称: | CALCIUM ION, Gap junction beta-2 protein | | 著者 | Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J. | | 登録日 | 2015-11-13 | | 公開日 | 2016-01-27 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (3.286 Å) | | 主引用文献 | An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.
Nat Commun, 7, 2016
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3N8I
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3NJO
 | | X-ray crystal structure of the Pyr1-pyrabactin A complex | | 分子名称: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYR1, CHLORIDE ION, ... | | 著者 | Burgie, E.S, Bingman, C.A, Phillips Jr, G.N, Peterson, F.C, Volkman, B.F, Cutler, S.R, Jensen, D.R, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2010-06-17 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.473 Å) | | 主引用文献 | Structural basis for selective activation of ABA receptors.
Nat.Struct.Mol.Biol., 17, 2010
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3NJ1
 | | X-ray crystal structure of the PYL2(V114I)-pyrabactin A complex | | 分子名称: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL2, GLYCEROL, ... | | 著者 | Peterson, F.C, Burgie, E.S, Bingman, C.A, Volkman, B.F, Phillips Jr, G.N, Cutler, S.R, Jensen, D.R, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2010-06-16 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.948 Å) | | 主引用文献 | Structural basis for selective activation of ABA receptors.
Nat.Struct.Mol.Biol., 17, 2010
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7M0D
 | | Pre-catalytic quaternary complex of DNA Polymerase Lambda with bound complementary DSB substrate and incoming dUMPNPP | | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. | | 登録日 | 2021-03-10 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining.
Nat Commun, 13, 2022
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3NYR
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