4FOG

Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid

Summary for 4FOG

• Entry DOI: 10.2210/pdb4fog/pdb
• Related: 3QJ7 4FOA 4FOX
• Descriptor: Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, ... (4 entities in total)
• Functional Keywords: structural genomics, tb structural genomics consortium, tbsgc, transferase, thymidylate synthase
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cytoplasm (By similarity): P67044
• Total number of polymer chains: 4
• Total formula weight: 122222.38

Authors

Reddy, M.C.M.,Bruning, J.B.,Harshbarger, W.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-06-20, release date: 2013-08-07, Last modification date: 2023-09-13)

• Primary citation: Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.; Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)