4FOA

Crystal Structure of the Mtb ThyA in Complex with 5-fluoro-dUMP

Summary for 4FOA

• Entry DOI: 10.2210/pdb4foa/pdb
• Related: 3QJ7 4FOG 4FOX
• Descriptor: Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE (3 entities in total)
• Functional Keywords: structural genomics, tb structural genomics consortium, tbsgc, transferase, thymidylate synthase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 121192.32

Authors

Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-06-20, release date: 2013-08-07, Last modification date: 2023-09-13)

• Primary citation: Reddy, M.C.M.,Bruning, J.B.,Sacchettini, J.C.; Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition; To be Published,

Experimental method

X-RAY DIFFRACTION (2.253 Å)