4FQS

Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed

Summary for 4FQS

• Entry DOI: 10.2210/pdb4fqs/pdb
• Related: 3QJ7 4FOA 4FOG 4FOX
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, ... (4 entities in total)
• Functional Keywords: transferase, folate binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 61240.85

Authors

Reddy, M.C.M.,Bruning, J.B.,Harshbarger, W.,Sacchettini, J.C. (deposition date: 2012-06-25, release date: 2013-08-07, Last modification date: 2024-02-28)

• Primary citation: Reddy, M.C.M.,Bruning, J.B.,Harshbarger, W.,Sacchettini, J.C.; Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: insights into the selectivity and mode of inhibition; To be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)