8CGP
Insulin regulated aminopeptidase (IRAP) in complex with an allosteric aryl sulfonamide inhibitor
Summary for 8CGP
| Entry DOI | 10.2210/pdb8cgp/pdb |
| Descriptor | Leucyl-cystinyl aminopeptidase, pregnancy serum form, D-MALATE, ZINC ION, ... (15 entities in total) |
| Functional Keywords | insulin-regulated aminopeptidase, allosteric inhibitor, aryl sulfonamides, antigen presentation, hydrolase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 215838.61 |
| Authors | Mpakali, A.,Stratikos, E.,Giastas, P. (deposition date: 2023-02-06, release date: 2024-01-31, Last modification date: 2024-02-14) |
| Primary citation | Mpakali, A.,Barla, I.,Lu, L.,Ramesh, K.M.,Thomaidis, N.,Stern, L.J.,Giastas, P.,Stratikos, E. Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. J.Mol.Biol., 436:168449-168449, 2024 Cited by PubMed: 38244767DOI: 10.1016/j.jmb.2024.168449 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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