9BJU
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![BU of 9bju by Molmil](/molmil-images/mine/9bju) | Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5 | 分子名称: | 1,2-ETHANEDIOL, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ACETATE ION, ... | 著者 | Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A. | 登録日 | 2024-04-25 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability To Be Published
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1HZI
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![BU of 1hzi by Molmil](/molmil-images/mine/1hzi) | INTERLEUKIN-4 MUTANT E9A | 分子名称: | INTERLEUKIN-4, SULFATE ION | 著者 | Hulsmeyer, M, Scheufler, C, Dreyer, M.K. | 登録日 | 2001-01-25 | 公開日 | 2001-08-29 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation. Acta Crystallogr.,Sect.D, 57, 2001
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9BOL
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![BU of 9bol by Molmil](/molmil-images/mine/9bol) | Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5 | 分子名称: | (4R)-1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A. | 登録日 | 2024-05-03 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability To Be Published
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8H1T
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![BU of 8h1t by Molmil](/molmil-images/mine/8h1t) | Cryo-EM structure of BAP1-ASXL1 bound to chromatosome | 分子名称: | DNA (187-MER), Histone H1.4, Histone H2A type 1-D, ... | 著者 | Ge, W, Yu, C, Xu, R.M. | 登録日 | 2022-10-04 | 公開日 | 2023-02-01 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase. Nature, 616, 2023
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1IAR
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![BU of 1iar by Molmil](/molmil-images/mine/1iar) | INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX | 分子名称: | PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN), PROTEIN (INTERLEUKIN-4) | 著者 | Hage, T, Sebald, W, Reinemer, P. | 登録日 | 1999-02-25 | 公開日 | 2000-03-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Cell(Cambridge,Mass.), 97, 1999
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1HIJ
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![BU of 1hij by Molmil](/molmil-images/mine/1hij) | |
2XWU
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![BU of 2xwu by Molmil](/molmil-images/mine/2xwu) | |
7XZZ
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![BU of 7xzz by Molmil](/molmil-images/mine/7xzz) | Cryo-EM structure of the nucleosome in complex with p53 | 分子名称: | Cellular tumor antigen p53, DNA (169-MER), Histone H2A type 1-B/E, ... | 著者 | Nishimura, M, Nozawa, K, Takizawa, Y, Kurumizaka, H. | 登録日 | 2022-06-03 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.07 Å) | 主引用文献 | Structural basis for p53 binding to its nucleosomal target DNA sequence. Pnas Nexus, 1, 2022
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2XYI
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![BU of 2xyi by Molmil](/molmil-images/mine/2xyi) | Crystal Structure of Nurf55 in complex with a H4 peptide | 分子名称: | DI(HYDROXYETHYL)ETHER, HISTONE H4, PROBABLE HISTONE-BINDING PROTEIN CAF1, ... | 著者 | Stirnimann, C.U, Nowak, A.J, Mueller, C.W. | 登録日 | 2010-11-17 | 公開日 | 2011-05-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Chromatin-Modifying Complex Component Nurf55/P55 Associates with Histones H3, H4 and Polycomb Repressive Complex 2 Subunit Su(Z)12 Through Partially Overlapping Binding Sites. J.Biol.Chem., 286, 2011
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2XHI
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![BU of 2xhi by Molmil](/molmil-images/mine/2xhi) | Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase | 分子名称: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | 著者 | Dalhus, B, Forsbring, M, Helle, I.H, Backe, P.H, Forstrom, R.J, Alseth, I, Bjoras, M. | 登録日 | 2010-06-16 | 公開日 | 2011-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Separation-of-Function Mutants Unravel the Dual- Reaction Mode of Human 8-Oxoguanine DNA Glycosylase. Structure, 19, 2011
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2XL2
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2Y5K
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![BU of 2y5k by Molmil](/molmil-images/mine/2y5k) | Orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase | 分子名称: | 1-[5-(2-METHOXYETHYL)-4-METHYL-THIOPHEN-2-YL]SULFONYL-3-[4-METHOXY-6-(METHYLCARBAMOYLAMINO)PYRIDIN-2-YL]UREA, FRUCTOSE-1,6-BISPHOSPHATASE 1 | 著者 | Ruf, A, Hebeisen, P, Haap, W, Kuhn, B, Mohr, P, Wessel, H.P, Zutter, U, Kirchner, S, Benz, J, Joseph, C, Alvarez-Sanchez, R, Gubler, M, Schott, B, Benardeau, A, Tozzo, E, Kitas, E. | 登録日 | 2011-01-14 | 公開日 | 2011-05-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Orally Active Aminopyridines as Inhibitors of Tetrameric Fructose-1,6-Bisphosphatase. Bioorg.Med.Chem.Lett., 21, 2011
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5L6Y
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![BU of 5l6y by Molmil](/molmil-images/mine/5l6y) | il13 in complex with tralokinumab | 分子名称: | FORMIC ACID, Interleukin-13, tralokinumab FAb digest VH, ... | 著者 | Breed, J. | 登録日 | 2016-06-01 | 公開日 | 2016-12-21 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R alpha 1 and IL-13R alpha 2. J. Mol. Biol., 429, 2017
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2Y5L
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![BU of 2y5l by Molmil](/molmil-images/mine/2y5l) | orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase | 分子名称: | FRUCTOSE-1,6-BISPHOSPHATASE 1, N-{[(2Z)-5-bromo-1,3-thiazol-2(3H)-ylidene]carbamoyl}-3-chlorobenzenesulfonamide | 著者 | ruf, a, hebeisen, p, haap, w, kuhn, b, mohr, p, wessel, h.p, zutter, u, kirchner, s, benz, j, joseph, c, alvarez-sanchez, r, gubler, m, schott, b, benardeau, a, tozzo, e, kitas, e. | 登録日 | 2011-01-14 | 公開日 | 2011-05-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Orally Active Aminopyridines as Inhibitors of Tetrameric Fructose-1,6-Bisphosphatase. Bioorg.Med.Chem.Lett., 21, 2011
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8HPO
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![BU of 8hpo by Molmil](/molmil-images/mine/8hpo) | Cryo-EM structure of a SIN3/HDAC complex from budding yeast | 分子名称: | Histone deacetylase RPD3, PHOSPHOTHREONINE, POTASSIUM ION, ... | 著者 | Guo, Z, Zhan, X, Wang, C. | 登録日 | 2022-12-12 | 公開日 | 2023-05-03 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structure of a SIN3-HDAC complex from budding yeast. Nat.Struct.Mol.Biol., 30, 2023
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6WL5
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![BU of 6wl5 by Molmil](/molmil-images/mine/6wl5) | Crystal structure of EcmrR C-terminal domain | 分子名称: | 1,2-ETHANEDIOL, CETYL-TRIMETHYL-AMMONIUM, CHLORIDE ION, ... | 著者 | Yang, Y, Liu, C, Liu, B. | 登録日 | 2020-04-18 | 公開日 | 2021-04-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
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4O1Y
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![BU of 4o1y by Molmil](/molmil-images/mine/4o1y) | Crystal structure of Porcine Pancreatic Phospholipase A2 in complex with 1-Naphthaleneacetic acid | 分子名称: | CALCIUM ION, NAPHTHALEN-1-YL-ACETIC ACID, Phospholipase A2, ... | 著者 | Dileep, K.V, Remya, C, Tintu, I, Mandal, P.K, Karthe, P, Haridas, M, Sadasivan, C. | 登録日 | 2013-12-16 | 公開日 | 2014-01-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of Porcine Pancreatic Phospholipase A2 in complex with 1-Naphthaleneacetic acid To be published
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4OPN
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6O9M
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![BU of 6o9m by Molmil](/molmil-images/mine/6o9m) | Structure of the human apo TFIIH | 分子名称: | CDK-activating kinase assembly factor MAT1, General transcription factor IIH subunit 1, General transcription factor IIH subunit 2, ... | 著者 | Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I. | 登録日 | 2019-03-14 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. Nat.Struct.Mol.Biol., 26, 2019
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5W3I
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![BU of 5w3i by Molmil](/molmil-images/mine/5w3i) | Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6e (SRI-29685) | 分子名称: | 5-hydroxy-N-(2-methoxyethyl)-6-oxo-2-[(2S)-1-(phenoxyacetyl)pyrrolidin-2-yl]-1,6-dihydropyrimidine-4-carboxamide, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-06-07 | 公開日 | 2017-12-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7, 2017
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5WEB
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![BU of 5web by Molmil](/molmil-images/mine/5web) | Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10e (SRI-30024) | 分子名称: | 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-07-08 | 公開日 | 2018-01-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.254 Å) | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7, 2017
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5WB3
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![BU of 5wb3 by Molmil](/molmil-images/mine/5wb3) | Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10j (SRI-30026) | 分子名称: | 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-ox o-1,6-dihydropyrimidine-4-carboxamide, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-06-27 | 公開日 | 2018-01-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7, 2017
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7OHA
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![BU of 7oha by Molmil](/molmil-images/mine/7oha) | |
2FUU
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![BU of 2fuu by Molmil](/molmil-images/mine/2fuu) | |
6LTJ
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![BU of 6ltj by Molmil](/molmil-images/mine/6ltj) | Structure of nucleosome-bound human BAF complex | 分子名称: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | 登録日 | 2020-01-22 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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