PDB: 1345 件ウェブページステータス検索Chemie searchBIRD

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5BWM	The complex structure of C3cer exoenzyme and GDP bound RhoA (NADH-bound state) 分子名称: 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ADP-ribosyltransferase, ... 著者 Toda, A, Tsurumura, T, Yoshida, T, Tsuge, H. 登録日 2015-06-08 公開日 2015-06-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Rho GTPase Recognition by C3 Exoenzyme Based on C3-RhoA Complex Structure. J.Biol.Chem., 290, 2015
5BXQ	Structure of the NTF2:RanGDP complex 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Stewart, M. 登録日 2015-06-09 公開日 2015-07-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. J.Mol.Biol., 277, 1998
2KWI	RalB-RLIP76 (RalBP1) complex 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RalA-binding protein 1, ... 著者 Fenwick, R.B, Campbell, L.J, Rajasekar, K, Prasannan, S, Nietlispach, D, Camonis, J, Owen, D, Mott, H.R. 登録日 2010-04-12 公開日 2010-09-01 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction Structure, 18, 2010
7SD0	Cryo-EM structure of the SHOC2:PP1C:MRAS complex 分子名称: Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ... 著者 Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J. 登録日 2021-09-29 公開日 2022-04-20 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Structural basis for SHOC2 modulation of RAS signalling. Nature, 609, 2022
7SCW	KRAS full length wild-type in complex with RGL1 Ras association domain 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... 著者 Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. 登録日 2021-09-29 公開日 2022-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant. J.Mol.Biol., 434, 2022
7SCX	KRAS full-length G12V in complex with RGL1 Ras association domain 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... 著者 Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. 登録日 2021-09-29 公開日 2022-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant. J.Mol.Biol., 434, 2022
2A78	Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mono-ADP-ribosyltransferase C3, ... 著者 Pautsch, A, Vogelsgesang, M, Trankle, J, Herrmann, C, Aktories, K. 登録日 2005-07-05 公開日 2005-10-11 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. Embo J., 24, 2005
2A9K	Crystal structure of the C3bot-NAD-RalA complex reveals a novel type of action of a bacterial exoenzyme 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mono-ADP-ribosyltransferase C3, ... 著者 Pautsch, A, Vogelsgesang, M, Trankle, J, Herrmann, C, Aktories, K. 登録日 2005-07-12 公開日 2005-10-11 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. Embo J., 24, 2005
4LWZ	Crystal structure of Myo5b globular tail domain in complex with inactive Rab11a 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-11A, ... 著者 Pylypenko, O, Attanda, W, Gauquelin, C, Houdusse, A. 登録日 2013-07-29 公開日 2013-11-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural basis of myosin V Rab GTPase-dependent cargo recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
4M8N	Crystal Structure of PlexinC1/Rap1B Complex 分子名称: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Pascoe, H.G, Wang, Y, Brautigam, C.A, He, H, Zhang, X. 登録日 2013-08-13 公開日 2013-10-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.294 Å) 主引用文献 Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin. Elife, 2, 2013
1HE8	Ras G12V - PI 3-kinase gamma complex 分子名称: MAGNESIUM ION, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM, ... 著者 Pacold, M.E, Suire, S, Perisic, O, Lara-Gonzalez, S, Davis, C.T, Hawkins, P.T, Walker, E.H, Stephens, L, Eccleston, J.F, Williams, R.L. 登録日 2000-11-20 公開日 2001-01-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal Structure and Functional Analysis of Ras Binding to its Effector Phosphoinositide 3-Kinase Gamma Cell(Cambridge,Mass.), 103, 2000
4MIT	Crystal structure of E. histolytica RacC bound to the EhPAK4 PBD 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho family GTPase, ... 著者 Bosch, D.E, Siderovski, D.P. 登録日 2013-09-02 公開日 2014-09-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors. Biochemistry, 54, 2015
1GRN	CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX. 分子名称: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Nassar, N, Hoffman, G.R, Clardy, J.C, Cerione, R.A. 登録日 1998-07-30 公開日 1999-12-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nat.Struct.Biol., 5, 1998
1GZS	CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN Cdc42 分子名称: GTP-BINDING PROTEIN, SOPE, SULFATE ION 著者 Buchwald, G, Friebel, A, Galan, J.E, Hardt, W.D, Wittinghofer, A, Scheffzek, K. 登録日 2002-06-05 公開日 2002-09-12 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Basis for the Reversible Activation of a Rho Protein by the Bacterial Toxin Sope Embo J., 21, 2002
1HH4	Rac1-RhoGDI complex involved in NADPH oxidase activation 分子名称: GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Grizot, S, Faure, J, Fieschi, F, Vignais, P.V, Dagher, M.-C, Pebay-Peyroula, E. 登録日 2000-12-20 公開日 2001-08-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structure of the Rac1-Rhogdi Complex Involved in Nadph Oxidase Activation Biochemistry, 40, 2001
5JLJ	Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ... 著者 Fung, H.Y, Chook, Y.M. 登録日 2016-04-27 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30, 2016
4URW	The crystal structure of H-Ras and SOS in complex with ligands 分子名称: 2-(2,6-DIMETHYLPHENYL)-4-(METHYLSULFANYL)-6-(PIPERAZIN-1-YL)-1,3,5-TRIAZINE, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1 著者 Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. 登録日 2014-07-02 公開日 2015-03-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015
4URY	The crystal structure of H-Ras and SOS in complex with ligands 分子名称: GTPASE HRAS, N-[(4-aminophenyl)sulfonyl]cyclopropanecarboxamide, SON OF SEVENLESS HOMOLOG 1 著者 Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. 登録日 2014-07-02 公開日 2015-03-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015
1AM4	COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS) 分子名称: CDC42HS, MAGNESIUM ION, P50-RHOGAP, ... 著者 Rittinger, K, Walker, P, Gamblin, S.J, Smerdon, S.J. 登録日 1997-06-22 公開日 1998-07-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature, 388, 1997
4US0	The crystal structure of H-Ras and SOS in complex with ligands 分子名称: 1-ETHYL-PYRROLIDINE-2,5-DIONE, GTPase HRas, Son of sevenless homolog 1 著者 Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. 登録日 2014-07-02 公開日 2015-03-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015
4URZ	The crystal structure of H-Ras and SOS in complex with ligands 分子名称: 1-[(4-aminophenyl)sulfonyl]piperidin-2-one, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1 著者 Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. 登録日 2014-07-02 公開日 2015-03-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015
4URX	The crystal structure of H-Ras and SOS in complex with ligands 分子名称: 1-(4-bromobenzyl)pyrrolidine, 6-bromo-1H-indole, FORMIC ACID, ... 著者 Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. 登録日 2014-07-02 公開日 2015-03-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015
4URU	The crystal structure of H-Ras and SOS in complex with ligands 分子名称: 4-METHOXY-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1 著者 Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. 登録日 2014-07-02 公開日 2015-03-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015
5KHO	Rasip1 RA domain in complex with Rap1B 分子名称: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Gingras, A.R. 登録日 2016-06-15 公開日 2016-10-19 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins. Structure, 24, 2016
4WVF	Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1 分子名称: (2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Sun, Q, Chook, Y. 登録日 2014-11-05 公開日 2015-07-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Nat.Neurosci., 18, 2015

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