4URW
The crystal structure of H-Ras and SOS in complex with ligands
Summary for 4URW
Entry DOI | 10.2210/pdb4urw/pdb |
Related | 4URU 4URV 4URX 4URY 4URZ 4US0 4US1 4US2 |
Descriptor | GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, 2-(2,6-DIMETHYLPHENYL)-4-(METHYLSULFANYL)-6-(PIPERAZIN-1-YL)-1,3,5-TRIAZINE, ... (4 entities in total) |
Functional Keywords | signaling protein |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 |
Total number of polymer chains | 2 |
Total formula weight | 78576.42 |
Authors | Winter, J.J.G.,Anderson, M.,Blades, K.,Brassington, C.,Breeze, A.L.,Chresta, C.,Embrey, K.,Fairley, G.,Faulder, P.,Finlay, M.R.V.,Kettle, J.G.,Nowak, T.,Overman, R.,Patel, S.J.,Perkins, P.,Spadola, L.,Tart, J.,Tucker, J.,Wrigley, G. (deposition date: 2014-07-02, release date: 2015-03-04, Last modification date: 2024-01-10) |
Primary citation | Winter, J.,Anderson, M.,Blades, K.,Chresta, C.,Embrey, K.J.,Fairley, G.,Faulder, P.,Finlay, M.R.V.,Kettle, J.G.,Nowak, T.,Overman, R.,Patel, S.J.,Perkins, P.,Spadola, L.,Tart, J.,Tucker, J.A.,Wrigley, G. Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58:2265-, 2015 Cited by PubMed: 25695162DOI: 10.1021/JM501660T PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
Download full validation report