4URW

The crystal structure of H-Ras and SOS in complex with ligands

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	GTPASE HRAS	polymer	185	21083.6	1	UniProt (P01112) Pfam (PF00071)	HOMO SAPIENS (HUMAN)	H-RAS-1, HA-RAS, TRANSFORMING PROTEIN P21, C-H-RAS, P21RAS, H-RAS
2	B (S)	SON OF SEVENLESS HOMOLOG 1	polymer	487	57177.4	1	UniProt (Q07889) Pfam (PF00618) Pfam (PF00617)	HOMO SAPIENS (HUMAN)	SOS-1, SON OF SEVENLESS-1
3	C (S)	2-(2,6-DIMETHYLPHENYL)-4-(METHYLSULFANYL)-6-(PIPERAZIN-1-YL)-1,3,5-TRIAZINE	non-polymer		315.4	1	Chemie (DXO)
4	D, E (R, S)	water	water		18.0	200	Chemie (HOH)

Sequence modifications

R: 1 - 166 (UniProt: P01112)

PDB	External Database	Details
Met -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Gly -11	-	expression tag
Gly -10	-	expression tag
Gly -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

S: 564 - 1049 (UniProt: Q07889)

PDB	External Database	Details
Met 563	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	78261.0
Non-Polymers*	Number of molecules	1
	Total formula weight	315.4
All*	Total formula weight	78576.4

*Water molecules are not included.