4URY

The crystal structure of H-Ras and SOS in complex with ligands

Summary for 4URY

Related4URU 4URV 4URW 4URX 4URZ 4US0 4US1 4US2
DescriptorGTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, N-[(4-aminophenyl)sulfonyl]cyclopropanecarboxamide, ... (4 entities in total)
Functional Keywordssignaling protein
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane. Isoform 2: Nucleus P01112
Total number of polymer chains2
Total molecular weight78741.54
Authors
Primary citation
Winter, J.,Anderson, M.,Blades, K.,Chresta, C.,Embrey, K.J.,Fairley, G.,Faulder, P.,Finlay, M.R.V.,Kettle, J.G.,Nowak, T.,Overman, R.,Patel, S.J.,Perkins, P.,Spadola, L.,Tart, J.,Tucker, J.A.,Wrigley, G.
Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58:2265-, 2015
PubMed: 25695162 (PDB entries with the same primary citation)
DOI: 10.1021/JM501660T
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.47 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22200 3.4% 4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25