PDB: 237 件ウェブページステータス検索Chemie searchBIRD

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4RKA	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347 分子名称: 2-{[5-(naphthalen-1-ylmethyl)-4-oxo-4H-1lambda~4~,3-thiazol-2-yl]amino}benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Zhu, L, Ren, X, Zhu, J, Li, H. 登録日 2014-10-12 公開日 2015-11-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347 TO BE PUBLISHED
4RLI	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Zhu, L, Ren, X, Zhu, J, Li, H. 登録日 2014-10-17 公開日 2015-11-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048 TO BE PUBLISHED
4RK8	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 分子名称: 5-fluoro-2-{[(5Z)-5-(naphthalen-1-ylmethylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]amino}benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Zhu, L, Ren, X, Zhu, J, Li, H. 登録日 2014-10-12 公開日 2015-11-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 TO BE PUBLISHED
4CQ8	Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178 分子名称: 5-(4-cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Rowland, P. 登録日 2014-02-12 公開日 2014-04-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289, 2014
4CQA	Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6273 分子名称: 2-(4-chlorobenzyl)-8-ethoxy-1,3-dimethylcyclohepta[c]pyrrol-4(2H)-one, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Rowland, P. 登録日 2014-02-12 公開日 2014-04-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289, 2014
7UT5	Acinetobacter baumannii dihydroorotate dehydrogenase bound with inhibitor DSM186 分子名称: (4R)-7-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl]imidazo[1,2-a]pyrimidin-5-amine, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ... 著者 Deng, X, Phillips, M, Tomchick, D. 登録日 2022-04-26 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii. Proc.Natl.Acad.Sci.USA, 119, 2022
4CQ9	Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6253 分子名称: 6-(3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-[1,2,4]triazolo[3,4-a]phthalazine, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Rowland, P. 登録日 2014-02-12 公開日 2014-04-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289, 2014
4EF8	Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Pinheiro, M.P, Emery, F.S, Nonato, M.C. 登録日 2012-03-29 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19, 2013
4EF9	Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Pinheiro, M.P, Emery, F.S, Nonato, M.C. 登録日 2012-03-29 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19, 2013
4LS0	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033 分子名称: 2-{(E)-[2-(4-phenyl-1,3-thiazol-2-yl)hydrazinylidene]methyl}benzaldehyde, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Zhu, L, Li, H, Ren, X, Zhu, J. 登録日 2013-07-21 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DHO1B0033 To be Published
4XQ6	CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENSE from MYCOBACTERIUM TUBERCULOSIS 分子名称: CHLORIDE ION, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ... 著者 Kishor, C, Addlagatta, A. 登録日 2015-01-19 公開日 2016-01-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Dihydroorotate Dehydrogenase form Mycobacterium Tuberculosis To Be Published
4LS2	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313 分子名称: 2-[(E)-{2-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... 著者 Zhu, L, Li, H, Ren, X, Zhu, J. 登録日 2013-07-21 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313 To be Published
4LS1	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 分子名称: 2-[(E)-{2-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... 著者 Zhu, L, Li, H, Ren, X, Zhu, J. 登録日 2013-07-21 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 To be Published
4YLW	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Wu, D, Ouyang, P, Lu, W, Huang, J. 登録日 2015-03-06 公開日 2016-03-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound To Be Published
1JQV	The K213E mutant of Lactococcus lactis Dihydroorotate dehydrogenase A 分子名称: ACETIC ACID, Dihydroorotate dehydrogenase A, FLAVIN MONONUCLEOTIDE, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-09 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JRB	The P56A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-13 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
4ZMG	Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 分子名称: 1-(3,5-difluoro-3'-methoxybiphenyl-4-yl)-3-(1,3-thiazol-5-yl)urea, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... 著者 Ren, X.L, Zhu, J.S, Zhu, L.L, Li, H.L. 登録日 2015-05-04 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 To Be Published
4ZL1	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18X at 1.86 A resolution 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Huang, J, Wu, D, Ouyang, P, Lu, W, Pu, J. 登録日 2015-05-01 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18XYW at 1.86 A resolution To Be Published
1JUB	The K136E mutant of lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-24 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JQX	The R57A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-09 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JRC	The N67A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-13 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JUE	1.8 A resolution structure of native lactococcus lactis dihydroorotate dehydrogenase A 分子名称: ACETIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-24 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
4ORI	Rat dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Deng, X, Phillips, M.A. 登録日 2014-02-11 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors. J.Med.Chem., 57, 2014
4OQV	High resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) 分子名称: ACETIC ACID, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Deng, X, Phillips, M.A. 登録日 2014-02-10 公開日 2014-06-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors. J.Med.Chem., 57, 2014
4ORM	Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Deng, X, Phillips, M.A. 登録日 2014-02-11 公開日 2014-06-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors. J.Med.Chem., 57, 2014

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