9BKM

DHODH in complex with Ligand 10

This is a non-PDB format compatible entry.

Summary for 9BKM

• Entry DOI: 10.2210/pdb9bkm/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
• Functional Keywords: dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41496.32

Authors

Shaffer, P.L. (deposition date: 2024-04-29, release date: 2024-07-03)

• Primary citation: DeRatt, L.G.,Zhang, Z.,Pietsch, C.,Cisar, J.S.,Zhang, X.,Wang, W.,Tanner, A.,Matico, R.,Shaffer, P.,Jacoby, E.,Kazmi, F.,Shukla, N.,Bush, T.L.,Patrick, A.,Philippar, U.,Attar, R.,Edwards, J.P.,Kuduk, S.D.; Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.; J.Med.Chem., 2024; PubMed: 38889244; DOI: 10.1021/acs.jmedchem.4c00809

Experimental method

X-RAY DIFFRACTION (2.08 Å)