7T5Y
E. coli dihydroorotate dehydrogenase bound to the inhibitor HMNQ
Summary for 7T5Y
| Entry DOI | 10.2210/pdb7t5y/pdb |
| Related | 7T5K 7T6C 7T6H |
| Descriptor | Dihydroorotate dehydrogenase (quinone), 3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one, PHOSPHATE ION, ... (6 entities in total) |
| Functional Keywords | inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Escherichia coli K-12 |
| Total number of polymer chains | 2 |
| Total formula weight | 82457.18 |
| Authors | Horwitz, S.M.,Ambarian, J.A.,Davis, K.M. (deposition date: 2021-12-13, release date: 2022-03-02, Last modification date: 2023-10-18) |
| Primary citation | Horwitz, S.M.,Blue, T.C.,Ambarian, J.A.,Hoshino, S.,Seyedsayamdost, M.R.,Davis, K.M. Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines. Rsc Chem Biol, 3:420-425, 2022 Cited by PubMed: 35441142DOI: 10.1039/d1cb00255d PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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