PDB: 229 件ウェブページステータス検索Chemie searchBIRD

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3MAR	Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Yang, B, Peng, Y, Ding, J. 登録日 2010-03-24 公開日 2010-11-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res., 20, 2010
7E3N	Crystal structure of Isocitrate dehydrogenase D252N mutant from Trypanosoma brucei in complexed with NADP+, alpha-ketoglutarate, and ca2+ 分子名称: CALCIUM ION, ISOCITRIC ACID, Isocitrate dehydrogenase [NADP], ... 著者 Arai, N, Shiba, T, Inaoka, D.K, Kita, K, Wang, X, Otani, M, Matsushiro, S, Kojima, C. 登録日 2021-02-09 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Isocitrate dehydrogenase from Trypanosoma brucei. To Be Published
3MAS	Crystal structure of heterodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate 分子名称: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Yang, B, Peng, Y, Ding, J. 登録日 2010-03-24 公開日 2010-11-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res., 20, 2010
7E2W	Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with isocitrate and magnesium(II) 分子名称: CITRATE ANION, GLYCEROL, ISOCITRIC ACID, ... 著者 Zhu, G.P, Tang, W.G, Wang, P. 登録日 2021-02-07 公開日 2021-05-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs. Arch.Biochem.Biophys., 708, 2021
3MAP	Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate 分子名称: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Yang, B, Peng, Y, Ding, J. 登録日 2010-03-24 公開日 2010-11-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res., 20, 2010
3DMS	1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei 分子名称: Isocitrate dehydrogenase [NADP] 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2008-07-01 公開日 2008-07-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase. Biochemistry, 50, 2011
6L57	Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT , Mg and ATP binding at allosteric site. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, Isocitrate dehydrogenase [NAD] subunit alpha, ... 著者 Sun, P, Ding, J. 登録日 2019-10-22 公開日 2020-04-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.302 Å) 主引用文献 Molecular mechanism of the dual regulatory roles of ATP on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. Sci Rep, 10, 2020
6LTF	Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004 分子名称: BENZOIC ACID, Isocitrate dehydrogenase 著者 Zhu, G.P. 登録日 2020-01-22 公開日 2021-02-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004 To Be Published
6L59	Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT, Mg and ATP binding at allosteric site and Mg, ATP binding at active site. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, Isocitrate dehydrogenase [NAD] subunit alpha, ... 著者 Sun, P, Ding, J. 登録日 2019-10-22 公開日 2020-04-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.254 Å) 主引用文献 Molecular mechanism of the dual regulatory roles of ATP on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. Sci Rep, 10, 2020
6M3S	Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004 分子名称: GLYCEROL, ISOCITRATE CALCIUM COMPLEX, Isocitrate dehydrogenase, ... 著者 Zhu, G.P. 登録日 2020-03-04 公開日 2021-03-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004 To Be Published
6LKY	Crystal structure of isocitrate dehydrogenase from Methylococcus capsulatus 分子名称: ACETATE ION, ACETYL GROUP, CITRIC ACID, ... 著者 Huang, S, Wang, P, Zhu, G.P. 登録日 2019-12-21 公開日 2020-12-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of isocitrate dehydrogenase from Methylococcus capsulatus To Be Published
4HCX	Structure of ICDH-1 from M.tuberculosis complexed with NADPH & Mn2+ 分子名称: CHLORIDE ION, Isocitrate dehydrogenase [NADP], MANGANESE (II) ION, ... 著者 Hazra, S, Blanchard, J. 登録日 2012-10-01 公開日 2013-02-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Structural, Kinetic and Chemical Mechanism of Isocitrate Dehydrogenase-1 from Mycobacterium tuberculosis. Biochemistry, 52, 2013
6O2Z	Crystal structure of IDH1 R132H mutant in complex with compound 32 分子名称: 6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methylpyridine-3-carbonitrile, GLYCEROL, Isocitrate dehydrogenase [NADP] cytoplasmic, ... 著者 Toms, A.V, Lin, J. 登録日 2019-02-25 公開日 2019-06-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. J.Med.Chem., 62, 2019
5SUN	IDH1 R132H in complex with IDH146 分子名称: 1,2-ETHANEDIOL, 3-benzyl-N-[3-(dimethylsulfamoyl)phenyl]-4-oxo-3,4-dihydrophthalazine-1-carboxamide, DIMETHYL SULFOXIDE, ... 著者 Xie, X, Kulathila, R. 登録日 2016-08-03 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.477 Å) 主引用文献 Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
6O2Y	Crystal structure of IDH1 R132H mutant in complex with compound 24 分子名称: 4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methoxybenzonitrile, BETA-MERCAPTOETHANOL, Isocitrate dehydrogenase [NADP] cytoplasmic, ... 著者 Toms, A.V, Lin, J. 登録日 2019-02-25 公開日 2019-06-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. J.Med.Chem., 62, 2019
4I3K	Crystal structure of a metabolic reductase with 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one 分子名称: 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Zheng, B, Yao, Y, Liu, Z, Deng, L, Anglin, J.L, Jiang, H, Prasad, B.V.V, Song, Y. 登録日 2012-11-26 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.3056 Å) 主引用文献 Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett, 4, 2013
4I3L	Crystal structure of a metabolic reductase with 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one 分子名称: 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Zheng, B, Yao, Y, Liu, Z, Deng, L, Anglin, J.L, Jiang, H, Prasad, B.V.V, Song, Y. 登録日 2012-11-26 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.292 Å) 主引用文献 Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett, 4, 2013
5SVF	IDH1 R132H in complex with IDH125 分子名称: (4S)-3-(2-{[(1S)-1-phenylethyl]amino}pyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one, CITRATE ANION, Isocitrate dehydrogenase [NADP] cytoplasmic, ... 著者 Xie, X, Kulathila, R. 登録日 2016-08-05 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
5SVO	Structure of IDH2 mutant R140Q 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Isocitrate dehydrogenase [NADP], mitochondrial, ... 著者 Xie, X, Kulathila, R. 登録日 2016-08-06 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
4ICD	REGULATION OF ISOCITRATE DEHYDROGENASE BY PHOSPHORYLATION INVOLVES NO LONG-RANGE CONFORMATIONAL CHANGE IN THE FREE ENZYME 分子名称: PHOSPHORYLATED ISOCITRATE DEHYDROGENASE 著者 Hurley, J.H, Dean, A.M, Thorsness, P.E, Koshlandjunior, D.E, Stroud, R.M. 登録日 1989-12-28 公開日 1991-01-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. J.Biol.Chem., 265, 1990
5SVN	Structure of IDH2 mutant R172K 分子名称: DI(HYDROXYETHYL)ETHER, Isocitrate dehydrogenase [NADP], mitochondrial, ... 著者 Xie, X, Kulathila, R. 登録日 2016-08-06 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
1P8F	A four location model to explain the stereospecificity of proteins. 分子名称: GLYCEROL, ISOCITRIC ACID, Isocitrate dehydrogenase [NADP], ... 著者 Mesecar, A.D, Koshland Jr, D.E. 登録日 2003-05-07 公開日 2003-05-20 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural biology: A new model for protein stereospecificity. Nature, 403, 2000
5K11	Cryo-EM structure of isocitrate dehydrogenase (IDH1) in inhibitor-bound state 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Merk, A, Bartesaghi, A, Banerjee, S, Falconieri, V, Rao, P, Earl, L, Milne, J, Subramaniam, S. 登録日 2016-05-17 公開日 2016-06-08 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. Cell, 165, 2016
5K10	Cryo-EM structure of isocitrate dehydrogenase (IDH1) 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Merk, A, Bartesaghi, A, Banerjee, S, Falconieri, V, Rao, P, Earl, L, Milne, J, Subramaniam, S. 登録日 2016-05-17 公開日 2016-06-08 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. Cell, 165, 2016
1PB3	Sites of binding and orientation in a four location model for protein stereospecificity. 分子名称: GLYCEROL, Isocitrate dehydrogenase [NADP], SULFATE ION 著者 Mesecar, A.D, Koshland Jr, D.E. 登録日 2003-05-14 公開日 2003-06-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Sites of Binding and Orientation in a Four-Location Model for Protein Stereospecificity. IUBMB Life, 49, 2000

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