5SVO

Structure of IDH2 mutant R140Q

Summary for 5SVO

Entry DOI	10.2210/pdb5svo/pdb
Related	5SUN 5SVF 5SVN
Descriptor	Isocitrate dehydrogenase [NADP], mitochondrial, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	inhibitor, isocitrate dehydrogenase, mitochondrial, nadph, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion: P48735
Total number of polymer chains	2
Total formula weight	97898.60
Authors	Xie, X.,Kulathila, R. (deposition date: 2016-08-06, release date: 2017-02-08, Last modification date: 2024-03-06)
Primary citation	Xie, X.,Baird, D.,Bowen, K.,Capka, V.,Chen, J.,Chenail, G.,Cho, Y.,Dooley, J.,Farsidjani, A.,Fortin, P.,Kohls, D.,Kulathila, R.,Lin, F.,McKay, D.,Rodrigues, L.,Sage, D.,Toure, B.B.,van der Plas, S.,Wright, K.,Xu, M.,Yin, H.,Levell, J.,Pagliarini, R.A. Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25:506-513, 2017 Cited by PubMed: 28132785 DOI: 10.1016/j.str.2016.12.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation