5SVO

Structure of IDH2 mutant R140Q

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isocitrate dehydrogenase [NADP], mitochondrial	polymer	424	48086.7	2	UniProt (P48735) Pfam (PF00180)	Homo sapiens (Human)	IDH,ICD-M,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase
2	C, E (A, B)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	D (A)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
4	F, G (A, B)	water	water		18.0	413	Chemie (HOH)

Sequence modifications

A, B: 40 - 452 (UniProt: P48735)

PDB	External Database	Details
Gln 140	Arg 140	engineered mutation
Ser 453	-	expression tag
Leu 454	-	expression tag
Glu 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	96173.5
Non-Polymers*	Number of molecules	3
	Total formula weight	1725.1
All*	Total formula weight	97898.6

*Water molecules are not included.