6L59
Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT, Mg and ATP binding at allosteric site and Mg, ATP binding at active site.
Summary for 6L59
Entry DOI | 10.2210/pdb6l59/pdb |
Descriptor | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | tca cycle, nad-isocitrate dehydrogenase, oxidoreductase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 77355.44 |
Authors | |
Primary citation | Sun, P.,Bai, T.,Ma, T.,Ding, J. Molecular mechanism of the dual regulatory roles of ATP on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. Sci Rep, 10:6225-6225, 2020 Cited by PubMed: 32277159DOI: 10.1038/s41598-020-63425-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.254 Å) |
Structure validation
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