6L59
Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT, Mg and ATP binding at allosteric site and Mg, ATP binding at active site.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | polymer | 342 | 36957.5 | 1 | UniProt (P50213) Pfam (PF00180) | Homo sapiens (Human) | Isocitric dehydrogenase subunit alpha,NAD(+)-specific ICDH subunit alpha |
| 2 | B (B) | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial | polymer | 357 | 39142.9 | 1 | UniProt (P51553) Pfam (PF00180) | Homo sapiens (Human) | Isocitric dehydrogenase subunit gamma,NAD(+)-specific ICDH subunit gamma |
| 3 | C, E (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | G (B) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A: 1 - 339 (UniProt: P50213)
B: 1 - 354 (UniProt: P51553)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | initiating methionine |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | initiating methionine |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76100.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1255.1 | |
| All* | Total formula weight | 77355.4 |
