6L59

Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT, Mg and ATP binding at allosteric site and Mg, ATP binding at active site.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	polymer	342	36957.5	1	UniProt (P50213) Pfam (PF00180) In PDB	Homo sapiens (Human)	Isocitric dehydrogenase subunit alpha,NAD(+)-specific ICDH subunit alpha
2	B	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	polymer	357	39142.9	1	UniProt (P51553) Pfam (PF00180) In PDB	Homo sapiens (Human)	Isocitric dehydrogenase subunit gamma,NAD(+)-specific ICDH subunit gamma
3	A, B	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
4	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	B	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
6		water	water		18.0	200	Chemie (HOH)

Sequence modifications

A: 1 - 339 (UniProt: P50213)

PDB	External Database	Details
Met -2	-	initiating methionine
Gly -1	-	expression tag
Ser 0	-	expression tag

B: 1 - 354 (UniProt: P51553)

PDB	External Database	Details
Met -2	-	initiating methionine
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76100.3
Non-Polymers*	Number of molecules	5
	Total formula weight	1255.1
All*	Total formula weight	77355.4

*Water molecules are not included.