6L57

Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT , Mg and ATP binding at allosteric site.

Summary for 6L57

• Entry DOI: 10.2210/pdb6l57/pdb
• Descriptor: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: tca cycle, nad-isocitrate dehydrogenase, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 76848.26

Authors

Sun, P.,Ding, J. (deposition date: 2019-10-22, release date: 2020-04-29, Last modification date: 2023-11-22)

• Primary citation: Sun, P.,Bai, T.,Ma, T.,Ding, J.; Molecular mechanism of the dual regulatory roles of ATP on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.; Sci Rep, 10:6225-6225, 2020; PubMed: 32277159; DOI: 10.1038/s41598-020-63425-6

Experimental method

X-RAY DIFFRACTION (2.302 Å)