PDB: 282 件ウェブページステータス検索Chemie searchBIRD

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5VC1	Crystal structure of L-selectin lectin/EGF domains 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Wedepohl, S, Dernedde, J, Vahedi-Faridi, A, Tauber, R, Saenger, W, Bulut, H. 登録日 2017-03-30 公開日 2017-06-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 angstrom Resolution. Chembiochem, 18, 2017
5JZU	Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine and factor X substrate peptide fragment (26mer) 分子名称: Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, MANGANESE (II) ION, ... 著者 McDonough, M.A, Pfeffer, I. 登録日 2016-05-17 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun, 10, 2019
5JQY	Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine and factor X substrate peptide fragment(39mer-4Ser) 分子名称: ACETATE ION, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... 著者 McDonough, M.A, Pfeffer, I. 登録日 2016-05-05 公開日 2017-05-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun, 10, 2019
5JZ8	Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine, and factor X substrate peptide fragment (39mer) 分子名称: ACETATE ION, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... 著者 McDonough, M.A, Pfeffer, I. 登録日 2016-05-16 公開日 2017-05-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.095 Å) 主引用文献 Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun, 10, 2019
5JTC	Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, 2,4-pyridine dicarboxylate and factor X substrate peptide fragment(39mer-4Ser) 分子名称: Aspartyl/asparaginyl beta-hydroxylase, BROMIDE ION, Coagulation factor X, ... 著者 McDonough, M.A, Pfeffer, I. 登録日 2016-05-09 公開日 2017-05-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Aspartate/asparagine-beta-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors. Sci Rep, 10, 2020
5KY2	mouse POFUT1 in complex with O-glucosylated mouse Factor VII EGF1 and GDP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor VII, GDP-fucose protein O-fucosyltransferase 1, ... 著者 Li, Z, Rini, J.M. 登録日 2016-07-20 公開日 2017-05-17 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1. Nat. Chem. Biol., 13, 2017
5KXH	mouse POFUT1 in complex with mouse Factor VII EGF1 and GDP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor VII, GDP-fucose protein O-fucosyltransferase 1, ... 著者 Li, Z, Rini, J.M. 登録日 2016-07-20 公開日 2017-05-17 最終更新日 2021-03-24 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1. Nat. Chem. Biol., 13, 2017
5KY3	mouse POFUT1 in complex with mouse Factor VII EGF1 mutant (T101A) and GDP-fucose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor VII, GDP-fucose protein O-fucosyltransferase 1, ... 著者 Li, Z, Rini, J.M. 登録日 2016-07-21 公開日 2017-05-17 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1. Nat. Chem. Biol., 13, 2017
5UK5	Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Garcia, K.C, Luca, V.C. 登録日 2017-01-19 公開日 2017-03-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.506 Å) 主引用文献 Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science, 355, 2017
5JVY	Crystal structure of S121P murine COX-2 mutant 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ... 著者 Orlando, B.J, Malkowski, M.G, Dong, L. 登録日 2016-05-11 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. J.Biol.Chem., 291, 2016
5JVZ	Crystal structure of flurbiprofen bound to S121P murine COX-2 mutant 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Malkowski, M.G, Orlando, B.J. 登録日 2016-05-11 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. J.Biol.Chem., 291, 2016
5JW1	Crystal structure of Celecoxib bound to S121P murine COX-2 mutant 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, ... 著者 Malkowski, M.G, Orlando, B.J. 登録日 2016-05-11 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.822 Å) 主引用文献 Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. J.Biol.Chem., 291, 2016
5F86	Crystal structure of Drosophila Poglut1 (Rumi) complexed with its substrate protein (EGF repeat) 分子名称: Coagulation factor IX, GLYCEROL, O-glucosyltransferase rumi, ... 著者 Yu, H.J, Li, H.L. 登録日 2015-12-09 公開日 2016-07-20 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nat. Chem. Biol., 12, 2016
5F84	Crystal structure of Drosophila Poglut1 (Rumi) complexed with its glycoprotein product (glucosylated EGF repeat) and UDP 分子名称: Coagulation factor IX, O-glucosyltransferase rumi, SULFATE ION, ... 著者 Yu, H.J, Li, H.L. 登録日 2015-12-09 公開日 2016-07-20 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nat. Chem. Biol., 12, 2016
5F85	Crystal structure of Drosophila Poglut1 (Rumi) complexed with its substrate protein (EGF repeat) and UDP 分子名称: Coagulation factor IX, GLYCEROL, O-glucosyltransferase rumi, ... 著者 Yu, H.J, Li, H.L. 登録日 2015-12-09 公開日 2016-07-20 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nat. Chem. Biol., 12, 2016
5FM9	human Notch 1, EGF 4-7 分子名称: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 著者 Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C. 登録日 2015-11-02 公開日 2016-04-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies. Structure, 24, 2016
5FMA	human Notch 1, EGF 4-7 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... 著者 Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C. 登録日 2015-11-02 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies. Structure, 24, 2016
5FDQ	Murine COX-2 S530T mutant 分子名称: 2-[(2~{R})-2-(hydroxymethyloxy)propoxy]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lucido, M.J, Orlando, B.J, Malkowski, M.G. 登録日 2015-12-16 公開日 2016-03-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry, 55, 2016
4ZH8	Factor Xa complex with GTC000006 分子名称: 6-chloro-N-{(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxo-2,3-dihydro-1H-pyrrol-3-yl}-N-(2-oxobutyl)naphthalene-2-sulfonamide, CALCIUM ION, Coagulation factor X 著者 Convery, M.A. 登録日 2015-04-24 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Factor Xa complex with GTC000006 To Be Published
4ZHA	Factor Xa complex with GTC000102 分子名称: 4-[(3S)-3-({[(E)-2-(5-chlorothiophen-2-yl)ethenyl]sulfonyl}amino)-2-oxo-2,3-dihydro-1H-pyrrol-1-yl]-3-fluoro-N-methylbenzamide, CALCIUM ION, Coagulation factor X, ... 著者 Convery, M.A. 登録日 2015-04-24 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Factor Xa complex with GTC000102 To Be Published
4Z6A	Crystal Structure of a FVIIa-Trypsin Chimera (YT) in Complex with Soluble Tissue Factor 分子名称: CALCIUM ION, CITRIC ACID, Coagulation factor VII, ... 著者 Sorensen, A.B, Svensson, L.A, Gandhi, P.S. 登録日 2015-04-04 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity. J.Biol.Chem., 291, 2016
4ZMA	Crystal Structure of a FVIIa-Trypsin Chimera (ST) in Complex with Soluble Tissue Factor 分子名称: CACODYLATE ION, CALCIUM ION, Coagulation factor VII, ... 著者 Sorensen, A.B, Svensson, L.A, Gandhi, P.S. 登録日 2015-05-02 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity. J.Biol.Chem., 291, 2016
4YLQ	Crystal Structure of a FVIIa-Trypsin Chimera (FT) in Complex with Soluble Tissue Factor 分子名称: CALCIUM ION, Coagulation factor VII, N-PROPANOL, ... 著者 Sorensen, A.B, Svensson, L.A, Gandhi, P.S. 登録日 2015-03-05 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity. J.Biol.Chem., 291, 2016
5BO1	Crystal structure of a human Jag1 fragment in complex with an anti-Jag1 Fab 分子名称: Fab heavy chain, Fab light chain, GLYCEROL, ... 著者 Payandeh, J, de Leon-Boenig, G. 登録日 2015-05-26 公開日 2015-11-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung. Nature, 528, 2015
4WMA	Crystal structure of mouse Xyloside xylosyltransferase 1 complexed with manganese,acceptor ligand and UDP-Glucose 分子名称: Coagulation factor IX, MANGANESE (II) ION, SULFATE ION, ... 著者 Yu, H, Li, H. 登録日 2014-10-08 公開日 2015-09-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Nat.Chem.Biol., 11, 2015

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