4ZMA

Crystal Structure of a FVIIa-Trypsin Chimera (ST) in Complex with Soluble Tissue Factor

Summary for 4ZMA

• Entry DOI: 10.2210/pdb4zma/pdb
• Related: 4YLQ
• Related PRD ID: PRD_000369
• Descriptor: Coagulation factor VII, Tissue factor, CALCIUM ION, ... (9 entities in total)
• Functional Keywords: fusion protein, trypsin-fold, protein-protein complex, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709; Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726
• Total number of polymer chains: 3
• Total formula weight: 71205.06

Authors

Sorensen, A.B.,Svensson, L.A.,Gandhi, P.S. (deposition date: 2015-05-02, release date: 2015-12-30, Last modification date: 2024-01-10)

• Primary citation: Sorensen, A.B.,Madsen, J.J.,Svensson, L.A.,Pedersen, A.A.,stergaard, H.,Overgaard, M.T.,Olsen, O.H.,Gandhi, P.S.; Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.; J.Biol.Chem., 291:4671-4683, 2016; PubMed: 26694616; DOI: 10.1074/jbc.M115.698613

Experimental method

X-RAY DIFFRACTION (2.3 Å)