4ZMA
Crystal Structure of a FVIIa-Trypsin Chimera (ST) in Complex with Soluble Tissue Factor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Coagulation factor VII | polymer | 152 | 17487.1 | 1 | UniProt (P08709) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (Human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA |
| 2 | B (H) | Coagulation factor VII | polymer | 249 | 27448.5 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (Human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA |
| 3 | C (T) | Tissue factor | polymer | 219 | 24826.5 | 1 | UniProt (P13726) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (Human) | TF,Coagulation factor III,Thromboplastin |
| 4 | D, E, F, G, H... (L, H) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 5 | K (L) | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
| 6 | L (L) | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) | |||
| 7 | M (H) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide | non-polymer | 504.0 | 1 | BIRD (PRD_000369) Chemie (0Z6) | |||
| 8 | O, P (H) | CACODYLATE ION | non-polymer | 137.0 | 2 | Chemie (CAC) | Homo sapiens (Human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA | |
| 9 | Q, R, S (L, H, T) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
H: 16 - 257 (UniProt: P08709)
| PDB | External Database | Details |
|---|---|---|
| Glu 169 | Leu 371 | engineered mutation |
| Ala 170 | Gln 372 | engineered mutation |
| Ser 171 | Gln 373 | engineered mutation |
| - | Arg 375 | deletion |
| - | Lys 376 | deletion |
| - | Val 377 | deletion |
| - | Gly 378 | deletion |
| - | Asp 379 | deletion |
| Pro 173 | Ser 380 | engineered mutation |
| Gly 174 | Pro 381 | engineered mutation |
| Lys 175 | Asn 382 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69762.1 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1443.0 | |
| All* | Total formula weight | 71205.1 |
