5JTC

Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, 2,4-pyridine dicarboxylate and factor X substrate peptide fragment(39mer-4Ser)

Summary for 5JTC

• Entry DOI: 10.2210/pdb5jtc/pdb
• Descriptor: Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, MANGANESE (II) ION, ... (7 entities in total)
• Functional Keywords: 2-oxoglutarate dependent oxygenase, aspartyl/asparaginyl beta-hydroxylase, egf-like domain hydroxylase, double stranded beta-helix, tetratricopeptide repeat, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Endoplasmic reticulum membrane; Single-pass type II membrane protein . Isoform 4: Sarcoplasmic reticulum membrane; Single-pass type II membrane protein . Isoform 8: Endoplasmic reticulum membrane; Single-pass type II membrane protein : Q12797; Secreted: P00742
• Total number of polymer chains: 2
• Total formula weight: 53989.78

Authors

McDonough, M.A.,Pfeffer, I. (deposition date: 2016-05-09, release date: 2017-05-24, Last modification date: 2024-01-10)

• Primary citation: Brewitz, L.,Tumber, A.,Pfeffer, I.,McDonough, M.A.,Schofield, C.J.; Aspartate/asparagine-beta-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.; Sci Rep, 10:8650-8650, 2020; PubMed: 32457455; DOI: 10.1038/s41598-020-65123-9

Experimental method

X-RAY DIFFRACTION (2.24 Å)