6FGS
| Solution structure of p300Taz2-p73TA1 | 分子名称: | Histone acetyltransferase p300,Tumor protein p73, ZINC ION | 著者 | Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V. | 登録日 | 2018-01-11 | 公開日 | 2018-05-30 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain. Structure, 26, 2018
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6GYR
| Transcription factor dimerization activates the p300 acetyltransferase | 分子名称: | Histone acetyltransferase p300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | 著者 | Panne, D, Ortega, E. | 登録日 | 2018-07-01 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Transcription factor dimerization activates the p300 acetyltransferase. Nature, 562, 2018
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6FGN
| Solution Structure of p300Taz2-p63TA | 分子名称: | Histone acetyltransferase p300,Tumor protein 63, ZINC ION | 著者 | Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V. | 登録日 | 2018-01-11 | 公開日 | 2018-05-30 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain. Structure, 26, 2018
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6DS6
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3P57
| Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA | 分子名称: | DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), Histone acetyltransferase p300, ... | 著者 | He, J, Ye, J, Riquelme, C, Liu, J.O. | 登録日 | 2010-10-08 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1921 Å) | 主引用文献 | Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic Acids Res., 39, 2011
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4PZT
| Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A | 分子名称: | DIMETHYL SULFOXIDE, Histone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE | 著者 | Maksimoska, J, Marmorstein, R. | 登録日 | 2014-03-31 | 公開日 | 2014-06-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues. Biochemistry, 53, 2014
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8E1D
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3BIY
| Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA | 分子名称: | BROMIDE ION, Histone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | 著者 | Liu, X, Wang, L, Zhao, K, Thompson, P.R, Hwang, Y, Marmorstein, R, Cole, P.A. | 登録日 | 2007-12-02 | 公開日 | 2008-02-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The structural basis of protein acetylation by the p300/CBP transcriptional coactivator Nature, 451, 2008
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5KJ2
| The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer | 分子名称: | Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION | 著者 | Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C. | 登録日 | 2016-06-17 | 公開日 | 2017-09-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature, 550, 2017
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2K8F
| Structural Basis for the Regulation of p53 Function by p300 | 分子名称: | Cellular tumor antigen p53, Histone acetyltransferase p300 | 著者 | Bai, Y, Feng, H, Jenkins, L.M, Durell, S.R, Wiodawer, A, Appella, E. | 登録日 | 2008-09-08 | 公開日 | 2009-03-03 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation. Structure, 17, 2009
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2MH0
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7W9V
| Cryo-EM structure of nucleosome in complex with p300 acetyltransferase catalytic core (complex I) | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Hatazawa, S, Liu, J, Takizawa, Y, Zandian, M, Negishi, L, Kutateladze, T.G, Kurumizaka, H. | 登録日 | 2021-12-10 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | 主引用文献 | Structural basis for binding diversity of acetyltransferase p300 to the nucleosome. Iscience, 25, 2022
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7LJE
| Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases | 分子名称: | 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methyl-acetamide, Histone acetyltransferase p300 | 著者 | Jakob, C.G. | 登録日 | 2021-01-29 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.607 Å) | 主引用文献 | Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases. Bioorg.Med.Chem.Lett., 39, 2021
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7XEZ
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7XFG
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8HAG
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 1 (3.2 angstrom resolution) | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | 登録日 | 2022-10-26 | 公開日 | 2023-05-17 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAH
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (3.9 angstrom resolution) | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | 登録日 | 2022-10-26 | 公開日 | 2023-05-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAI
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 1 (4.7 angstrom resolution) | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | 登録日 | 2022-10-26 | 公開日 | 2023-05-17 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAJ
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (4.8 angstrom resolution) | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | 登録日 | 2022-10-26 | 公開日 | 2023-05-17 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAK
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 4 (4.5 angstrom resolution) | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | 登録日 | 2022-10-26 | 公開日 | 2023-05-17 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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4BHW
| Structural basis for autoinhibition of the acetyltransferase activity of p300 | 分子名称: | HISTONE ACETYLTRANSFERASE P300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | 著者 | Delvecchio, M, Gaucher, J, Aguilar-Gurrieri, C, Ortega, E, Panne, D. | 登録日 | 2013-04-08 | 公開日 | 2013-08-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | 主引用文献 | Structure of the P300 Catalytic Core and Implications for Chromatin Targeting and Hat Regulation Nat.Struct.Mol.Biol., 20, 2013
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5LKU
| Crystal structure of the p300 acetyltransferase catalytic core with coenzyme A. | 分子名称: | COENZYME A, Histone acetyltransferase p300,Histone acetyltransferase p300, ZINC ION | 著者 | Kaczmarska, Z, Ortega, E, Marquez, J.A, Panne, D. | 登録日 | 2016-07-25 | 公開日 | 2016-11-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of p300 in complex with acyl-CoA variants. Nat. Chem. Biol., 13, 2017
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5LKX
| Crystal structure of the p300 acetyltransferase catalytic core with propionyl-coenzyme A. | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Histone acetyltransferase p300,Histone acetyltransferase p300, ... | 著者 | Kaczmarska, Z, Ortega, E, Marquez, J.A, Panne, D. | 登録日 | 2016-07-25 | 公開日 | 2016-11-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Structure of p300 in complex with acyl-CoA variants. Nat. Chem. Biol., 13, 2017
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5LKT
| Crystal structure of the p300 acetyltransferase catalytic core with butyryl-coenzyme A. | 分子名称: | Butyryl Coenzyme A, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Kaczmarska, Z, Ortega, E, Marquez, J.A, Panne, D. | 登録日 | 2016-07-24 | 公開日 | 2016-11-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structure of p300 in complex with acyl-CoA variants. Nat. Chem. Biol., 13, 2017
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5LKZ
| Crystal structure of the p300 acetyltransferase catalytic core with crotonyl-coenzyme A. | 分子名称: | CROTONYL COENZYME A, GLYCEROL, Histone acetyltransferase p300,Histone acetyltransferase p300, ... | 著者 | Kaczmarska, Z, Ortega, E, Marquez, J.A, Panne, D. | 登録日 | 2016-07-25 | 公開日 | 2016-11-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of p300 in complex with acyl-CoA variants. Nat. Chem. Biol., 13, 2017
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