4PZT

Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A

Summary for 4PZT

Related4PZR 4PZS
DescriptorHistone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywordstransferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q09472
Total number of polymer chains1
Total molecular weight44759.68
Authors
Maksimoska, J.,Marmorstein, R. (deposition date: 2014-03-31, release date: 2014-06-11, Last modification date: 2014-06-25)
Primary citation
Maksimoska, J.,Segura-Pena, D.,Cole, P.A.,Marmorstein, R.
Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues.
Biochemistry, 53:3415-3422, 2014
PubMed: 24819397 (PDB entries with the same primary citation)
DOI: 10.1021/bi500380f
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2381203.0%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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