4PZT

Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SOP A 1701

Chain	Residue
A	TYR1397
A	TYR1446
A	LYS1456
A	ILE1457
A	PRO1458
A	ARG1462
A	LEU1463
A	TRP1466
A	HOH1819
A	HOH1836
A	HOH1849
A	LEU1398
A	HOH1855
A	ASP1399
A	SER1400
A	ARG1410
A	THR1411
A	TYR1414
A	TRP1436
A	PRO1440

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 1702

Chain	Residue
A	HIS1434
A	ILE1486
A	ASP1507
A	PHE1595
A	PHE1596
A	HOH1824

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 1703

Chain	Residue
A	TRP1436
A	HIS1591
A	VAL1594

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 1704

Chain	Residue
A	LYS1468
A	ASP1485
A	GLU1593
A	PHE1595
A	PHE1596

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"18273021","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24819397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17065153","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"15004546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---