4PZT
Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SOP A 1701 |
| Chain | Residue |
| A | TYR1397 |
| A | TYR1446 |
| A | LYS1456 |
| A | ILE1457 |
| A | PRO1458 |
| A | ARG1462 |
| A | LEU1463 |
| A | TRP1466 |
| A | HOH1819 |
| A | HOH1836 |
| A | HOH1849 |
| A | LEU1398 |
| A | HOH1855 |
| A | ASP1399 |
| A | SER1400 |
| A | ARG1410 |
| A | THR1411 |
| A | TYR1414 |
| A | TRP1436 |
| A | PRO1440 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 1702 |
| Chain | Residue |
| A | HIS1434 |
| A | ILE1486 |
| A | ASP1507 |
| A | PHE1595 |
| A | PHE1596 |
| A | HOH1824 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 1703 |
| Chain | Residue |
| A | TRP1436 |
| A | HIS1591 |
| A | VAL1594 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 1704 |
| Chain | Residue |
| A | LYS1468 |
| A | ASP1485 |
| A | GLU1593 |
| A | PHE1595 |
| A | PHE1596 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24819397 |
| Chain | Residue | Details |
| A | LEU1398 | |
| A | ARG1410 | |
| A | ILE1457 | |
| A | ARG1462 | |
| A | TRP1466 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17065153 |
| Chain | Residue | Details |
| A | LYS1336 | |
| A | LYS1473 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546 |
| Chain | Residue | Details |
| A | LYS1499 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18995842, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS1542 | |
| A | LYS1546 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546, ECO:0000269|PubMed:18995842 |
| Chain | Residue | Details |
| A | LYS1549 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS1554 | |
| A | LYS1560 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS1555 | |
| A | LYS1583 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:15004546, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS1558 |
