4PZT
Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase p300 | polymer | 378 | 43701.7 | 1 | UniProt (Q09472) Pfam (PF08214) | Homo sapiens (human) | p300 HAT, E1A-associated protein p300 |
| 2 | B (A) | [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE | non-polymer | 823.6 | 1 | Chemie (SOP) | |||
| 3 | C, D, E (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 4 | F (A) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A: 1287 - 1664 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Phe 1467 | Tyr 1467 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43701.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1058.0 | |
| All* | Total formula weight | 44759.7 |
