7LJE

Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases

Summary for 7LJE

• Entry DOI: 10.2210/pdb7lje/pdb
• Descriptor: Histone acetyltransferase p300, 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methyl-acetamide (3 entities in total)
• Functional Keywords: histone acetylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 163518.22

Authors

Jakob, C.G. (deposition date: 2021-01-29, release date: 2021-03-17, Last modification date: 2023-10-18)

• Primary citation: Ji, Z.,Clark, R.F.,Bhat, V.,Matthew Hansen, T.,Lasko, L.M.,Bromberg, K.D.,Manaves, V.,Algire, M.,Martin, R.,Qiu, W.,Torrent, M.,Jakob, C.G.,Liu, H.,Cole, P.A.,Marmorstein, R.,Kesicki, E.A.,Lai, A.,Michaelides, M.R.; Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases.; Bioorg.Med.Chem.Lett., 39:127854-127854, 2021; PubMed: 33631370; DOI: 10.1016/j.bmcl.2021.127854

Experimental method

X-RAY DIFFRACTION (2.607 Å)