7LJE
Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0004402 | molecular_function | histone acetyltransferase activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue Y2P A 1701 |
| Chain | Residue |
| A | PHE1374 |
| A | TYR1446 |
| A | HIS1451 |
| A | PRO1452 |
| A | PRO1453 |
| A | GLN1455 |
| A | ILE1457 |
| A | PRO1458 |
| A | ARG1462 |
| A | LEU1463 |
| A | TRP1466 |
| A | LEU1398 |
| A | TYR1467 |
| A | HOH1830 |
| A | ASP1399 |
| A | SER1400 |
| A | TYR1414 |
| A | PRO1440 |
| A | GLU1442 |
| A | GLY1443 |
| A | ASP1444 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue Y2P B 1701 |
| Chain | Residue |
| B | PHE1374 |
| B | LEU1398 |
| B | ASP1399 |
| B | SER1400 |
| B | TYR1414 |
| B | PRO1440 |
| B | GLY1443 |
| B | ASP1444 |
| B | TYR1446 |
| B | PRO1453 |
| B | GLN1455 |
| B | LYS1456 |
| B | ILE1457 |
| B | PRO1458 |
| B | ARG1462 |
| B | LEU1463 |
| B | TRP1466 |
| B | TYR1467 |
| B | HOH1806 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue Y2P C 1701 |
| Chain | Residue |
| C | PHE1374 |
| C | LEU1398 |
| C | ASP1399 |
| C | SER1400 |
| C | TYR1414 |
| C | PRO1440 |
| C | GLU1442 |
| C | GLY1443 |
| C | ASP1444 |
| C | TYR1446 |
| C | HIS1451 |
| C | PRO1452 |
| C | PRO1453 |
| C | GLN1455 |
| C | PRO1458 |
| C | ARG1462 |
| C | LEU1463 |
| C | TRP1466 |
| C | TYR1467 |
| C | HOH1803 |
| C | HOH1848 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue Y2P D 1701 |
| Chain | Residue |
| D | PHE1374 |
| D | LEU1398 |
| D | ASP1399 |
| D | SER1400 |
| D | TYR1414 |
| D | PRO1440 |
| D | GLU1442 |
| D | GLY1443 |
| D | ASP1444 |
| D | TYR1446 |
| D | HIS1451 |
| D | PRO1453 |
| D | GLN1455 |
| D | ILE1457 |
| D | PRO1458 |
| D | ARG1462 |
| D | TRP1466 |
| D | TYR1467 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"18273021","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24819397","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17065153","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"15004546","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
