2K8F
Structural Basis for the Regulation of p53 Function by p300
Summary for 2K8F
Entry DOI | 10.2210/pdb2k8f/pdb |
NMR Information | BMRB: 15944 |
Descriptor | Histone acetyltransferase p300, Cellular tumor antigen p53 (2 entities in total) |
Functional Keywords | complex of p53 and p300, acetylation, bromodomain, cell cycle, chromosomal rearrangement, citrullination, disease mutation, host-virus interaction, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, transferase, zinc, zinc-finger, activator, alternative splicing, anti-oncogene, apoptosis, covalent protein-rna linkage, cytoplasm, dna-binding, endoplasmic reticulum, glycoprotein, li-fraumeni syndrome, ubl conjugation, transferase-transcription complex, transferase/transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: Q09472 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 14315.56 |
Authors | Bai, Y.,Feng, H.,Jenkins, L.M.,Durell, S.R.,Wiodawer, A.,Appella, E. (deposition date: 2008-09-08, release date: 2009-03-03, Last modification date: 2024-05-22) |
Primary citation | Feng, H.,Jenkins, L.M.,Durell, S.R.,Hayashi, R.,Mazur, S.J.,Cherry, S.,Tropea, J.E.,Miller, M.,Wlodawer, A.,Appella, E.,Bai, Y. Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation. Structure, 17:202-210, 2009 Cited by PubMed: 19217391DOI: 10.1016/j.str.2008.12.009 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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