2K8F
Structural Basis for the Regulation of p53 Function by p300
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase p300 | polymer | 90 | 9963.8 | 1 | UniProt (Q09472) Pfam (PF02135) | Homo sapiens (Human) | E1A-associated protein p300 |
| 2 | B (B) | Cellular tumor antigen p53 | polymer | 39 | 4351.8 | 1 | UniProt (P04637) Pfam (PF08563) | Homo sapiens (Human) | Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13 |
Sequence modifications
A: 1 - 90 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Ala 16 | Cys 1738 | engineered mutation |
| Ala 24 | Cys 1746 | engineered mutation |
| Ala 67 | Cys 1789 | engineered mutation |
| Ala 68 | Cys 1790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 14315.6 | |
| All* | Total formula weight | 14315.6 |
