4BHW

Structural basis for autoinhibition of the acetyltransferase activity of p300

Summary for 4BHW

• Entry DOI: 10.2210/pdb4bhw/pdb
• Descriptor: HISTONE ACETYLTRANSFERASE P300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate, ... (4 entities in total)
• Functional Keywords: transferase, bromodomain, phd domain, ring domain, hat domain, enhanceosome
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 136652.84

Authors

Delvecchio, M.,Gaucher, J.,Aguilar-Gurrieri, C.,Ortega, E.,Panne, D. (deposition date: 2013-04-08, release date: 2013-08-14, Last modification date: 2023-12-20)

• Primary citation: Delvecchio, M.,Gaucher, J.,Aguilar-Gurrieri, C.,Ortega, E.,Panne, D.; Structure of the P300 Catalytic Core and Implications for Chromatin Targeting and Hat Regulation; Nat.Struct.Mol.Biol., 20:1040-, 2013; PubMed: 23934153; DOI: 10.1038/NSMB.2642

Experimental method

X-RAY DIFFRACTION (2.799 Å)