4BHW
Structural basis for autoinhibition of the acetyltransferase activity of p300
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | HISTONE ACETYLTRANSFERASE P300 | polymer | 578 | 67102.7 | 2 | UniProt (Q09472) Pfam (PF00439) Pfam (PF06001) Pfam (PF08214) In PDB | HOMO SAPIENS (HUMAN) | P300 HAT, E1A-ASSOCIATED PROTEIN P300 |
2 | A, B | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) | |||
3 | A, B | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | non-polymer | 994.8 | 2 | Chemie (01K) | |||
4 | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, B: 1043 - 1519 (UniProt: Q09472)
A, B: 1581 - 1666 (UniProt: Q09472)
PDB | External Database | Details |
---|---|---|
Gly 1033 | - | expression tag |
Ala 1034 | - | expression tag |
Met 1035 | - | expression tag |
Ala 1036 | - | expression tag |
Gly 1037 | - | expression tag |
Lys 1038 | - | expression tag |
Ala 1039 | - | expression tag |
Val 1040 | - | expression tag |
Pro 1041 | - | expression tag |
Met 1042 | - | expression tag |
Phe 1467 | Tyr 1467 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 1520 | - | linker |
Gly 1521 | - | linker |
Gly 1522 | - | linker |
Ser 1523 | - | linker |
Gly 1524 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 134205.4 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2447.5 | |
All* | Total formula weight | 136652.8 |