4S2Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4s2z by Molmil](/molmil-images/mine/4s2z) | |
8VLB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vlb by Molmil](/molmil-images/mine/8vlb) | Crystal structure of EloBC-VHL-CDO1 complex bound to compound 4 molecular glue | 分子名称: | CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ... | 著者 | Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G. | 登録日 | 2024-01-11 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 To Be Published
|
|
8VL9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vl9 by Molmil](/molmil-images/mine/8vl9) | Crystal structure of EloBC-VHL-CDO1 complex bound to compound 8 molecular glue | 分子名称: | CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ... | 著者 | Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G. | 登録日 | 2024-01-11 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 To Be Published
|
|
8WQA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wqa by Molmil](/molmil-images/mine/8wqa) | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1) | 分子名称: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
|
|
1TAC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1tac by Molmil](/molmil-images/mine/1tac) | |
8WQH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wqh by Molmil](/molmil-images/mine/8wqh) | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) | 分子名称: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
|
|
8WQB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wqb by Molmil](/molmil-images/mine/8wqb) | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) | 分子名称: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
|
|
4IEM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4iem by Molmil](/molmil-images/mine/4iem) | Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+ | 分子名称: | DNA (5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*C)-3'), DNA (5'-D(P*(3DR)P*GP*AP*TP*CP*G)-3'), ... | 著者 | Tsutakawa, S.E, Mol, C.D, Arvai, A.S, Tainer, J.A. | 登録日 | 2012-12-13 | 公開日 | 2013-01-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3936 Å) | 主引用文献 | Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes. J.Biol.Chem., 288, 2013
|
|
8WQE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wqe by Molmil](/molmil-images/mine/8wqe) | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1) | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
|
|
8WQF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wqf by Molmil](/molmil-images/mine/8wqf) | cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
|
|
1T05
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t05 by Molmil](/molmil-images/mine/1t05) | HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate | 分子名称: | GLYCEROL, MAGNESIUM ION, POL polyprotein, ... | 著者 | Tuske, S, Sarafianos, S.G, Ding, J, Arnold, E. | 登録日 | 2004-04-07 | 公開日 | 2004-05-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir Nat.Struct.Mol.Biol., 11, 2004
|
|
3ERK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3erk by Molmil](/molmil-images/mine/3erk) | THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025 | 分子名称: | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, EXTRACELLULAR REGULATED KINASE 2 | 著者 | Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-09 | 公開日 | 1999-07-22 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
|
|
6P7Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6p7z by Molmil](/molmil-images/mine/6p7z) | |
6PAF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6paf by Molmil](/molmil-images/mine/6paf) | |
6CBY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cby by Molmil](/molmil-images/mine/6cby) | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975 | 分子名称: | N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone | 著者 | ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-05 | 公開日 | 2018-03-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase. J.Med.Chem., 62, 2019
|
|
6CBX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cbx by Molmil](/molmil-images/mine/6cbx) | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, N-lysine methyltransferase SMYD2, ... | 著者 | ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-05 | 公開日 | 2018-03-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 to be published
|
|
2HZ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2hz9 by Molmil](/molmil-images/mine/2hz9) | Crystal structure of Lys12Val/Asn95Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.70 angstrom resolution. | 分子名称: | FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION | 著者 | Dubey, V.K, Lee, J, Somasundaram, T, Blaber, M. | 登録日 | 2006-08-08 | 公開日 | 2007-06-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and C terminus beta-Strand Interactions J.Mol.Biol., 371, 2007
|
|
8IJ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ij1 by Molmil](/molmil-images/mine/8ij1) | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | 著者 | Dai, Z, Liang, L, Yin, Y.X. | 登録日 | 2023-02-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
|
|
1TJZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1tjz by Molmil](/molmil-images/mine/1tjz) | |
6PWW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6pww by Molmil](/molmil-images/mine/6pww) | Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | 登録日 | 2019-07-23 | 公開日 | 2019-12-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nat Commun, 10, 2019
|
|
8W9F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w9f by Molmil](/molmil-images/mine/8w9f) | |
8W9E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w9e by Molmil](/molmil-images/mine/8w9e) | |
5D2M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5d2m by Molmil](/molmil-images/mine/5d2m) | Complex between human SUMO2-RANGAP1, UBC9 and ZNF451 | 分子名称: | 1,2-ETHANEDIOL, Ran GTPase-activating protein 1, SUMO-conjugating enzyme UBC9, ... | 著者 | Cappadocia, L, Lima, C.D. | 登録日 | 2015-08-05 | 公開日 | 2015-11-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase. Nat.Struct.Mol.Biol., 22, 2015
|
|
3WYG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3wyg by Molmil](/molmil-images/mine/3wyg) | Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex | 分子名称: | Exportin-1, GUANOSINE-5'-TRIPHOSPHATE, Gsp1p, ... | 著者 | Koyama, M, Shirai, N, Matsuura, Y. | 登録日 | 2014-08-26 | 公開日 | 2014-11-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex Cell Rep, 9, 2014
|
|
6W5I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w5i by Molmil](/molmil-images/mine/6w5i) | Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01) | 分子名称: | DNA (147-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. | 登録日 | 2020-03-13 | 公開日 | 2021-03-31 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | 主引用文献 | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
|
|