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8VL9

Crystal structure of EloBC-VHL-CDO1 complex bound to compound 8 molecular glue

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Summary for 8VL9
Entry DOI10.2210/pdb8vl9/pdb
Descriptorvon Hippel-Lindau disease tumor suppressor, Elongin-B, Elongin-C, ... (8 entities in total)
Functional Keywordsvhl, cdo1, vhl-small molecule-cdo1 ternary complex, degradation, apoptosis
Biological sourceHomo sapiens (human)
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Total number of polymer chains4
Total formula weight66504.03
Authors
Shu, W.,Ma, X.,Tutter, A.,Buckley, D.,Golosov, A.,Michaud, G. (deposition date: 2024-01-11, release date: 2024-03-13)
Primary citationTutter, A.,Buckley, D.,Golosov, A.,Ma, X.,Shu, W.,Michaud, G.
A small molecule VHL molecular glue degrader for cysteine dioxygenase 1
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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PDB entries from 2024-11-06

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