6CBX

Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497

Summary for 6CBX

• Entry DOI: 10.2210/pdb6cbx/pdb
• Descriptor: N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl )-1H-pyrrol-3-yl]methanone, ... (7 entities in total)
• Functional Keywords: smyd2 mtf9975 inhibitor, structural genomics, structural genomics consortium, sgc, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytosol : Q9NRG4
• Total number of polymer chains: 2
• Total formula weight: 101465.34

Authors

ZENG, H.,DONG, A.,Hutchinson, A.,Seitova, A.,TATLOCK, J.,KUMPF, R.,OWEN, A.,TAYLOR, A.,Casimiro-Garcia, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,BROWN, P.J.,WU, H.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-05, release date: 2018-03-14, Last modification date: 2024-03-13)

• Primary citation: ZENG, H.,DONG, A.,Hutchinson, A.,Seitova, A.,TATLOCK, J.,KUMPF, R.,OWEN, A.,TAYLOR, A.,Casimiro-Garcia, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,BROWN, P.J.,WU, H.,Structural Genomics Consortium (SGC); Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497; to be published,

Experimental method

X-RAY DIFFRACTION (1.94 Å)