1T05

HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate

Summary for 1T05

• Entry DOI: 10.2210/pdb1t05/pdb
• Related: 1RTD 1T03
• Descriptor: oligonucleotide template, oligonucleotide primer, POL polyprotein, ... (8 entities in total)
• Functional Keywords: hiv-1 reverse transcriptase, tenofovir, rt-dna complex, transferase-dna complex, transferase/dna
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P04585
• Total number of polymer chains: 4
• Total formula weight: 131187.19

Authors

Tuske, S.,Sarafianos, S.G.,Ding, J.,Arnold, E. (deposition date: 2004-04-07, release date: 2004-05-11, Last modification date: 2023-08-23)

• Primary citation: Tuske, S.,Sarafianos, S.G.,Clark Jr., A.D.,Ding, J.,Naeger, L.K.,White, K.L.,Miller, M.D.,Gibbs, C.S.,Boyer, P.L.,Clark, P.,Wang, G.,Gaffney, B.L.,Jones, R.A.,Jerina, D.M.,Hughes, S.H.,Arnold, E.; Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir; Nat.Struct.Mol.Biol., 11:469-474, 2004; PubMed: 15107837; DOI: 10.1038/nsmb760

Experimental method

X-RAY DIFFRACTION (3 Å)