1T05
HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (T) | oligonucleotide template | polymer | 27 | 8383.4 | 1 | |||
| 2 | B (P) | oligonucleotide primer | polymer | 21 | 6474.3 | 1 | |||
| 3 | C (A) | POL polyprotein | polymer | 558 | 64249.7 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | |
| 4 | D (B) | POL polyprotein | polymer | 437 | 51123.6 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus 1 | |
| 5 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | G (A) | [2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL-TRIPHOSPHATE | non-polymer | 447.2 | 1 | Chemie (TNV) | |||
| 7 | H, I, J, K, L (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 8 | M, N, O, P (T, P, A, B) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 1 - 558 (UniProt: P03366)
B: 1 - 429 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Cys 258 | Gln 425 | engineered mutation |
| Ser 280 | Cys 447 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 435 | engineered mutation |
| Gly 430 | - | cloning artifact |
| Gly 431 | - | cloning artifact |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
| His 437 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130230.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 956.3 | |
| All* | Total formula weight | 131187.2 |
