PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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3N3Z	Crystal structure of PDE9A (E406A) mutant in complex with IBMX 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, CHLORIDE ION, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ... 著者 Hou, J, Luo, H.-B, Chen, Y, Xu, J, Zhao, R, Zou, L. 登録日 2010-05-21 公開日 2011-04-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structure of PDE9A (E406A) mutation in complex with IBMX To be Published
4DSY	Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment CC24201 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-phenylpyridine-3-carboxylic acid, ... 著者 Feder, D, Hussein, W.M, Clayton, D.J, Kan, M, Schenk, G, McGeary, R.P, Guddat, L.W. 登録日 2012-02-20 公開日 2012-09-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem.Biol.Drug Des., 80, 2012
4DKM	Crystal Structure of Amphioxus GFPc1a 分子名称: Amphioxus Green Fluorescent Protein, GFPc1a 著者 Deheyn, D.D, Bomati, E.K. 登録日 2012-02-03 公開日 2013-05-15 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fluorescent proteins in Amphioxus have strickingly different brightness, yet only few (but key) molecular differences To be Published
4DES	Crystal Structure of the Wild Type TTR Binding Chrysin (TTRwt:CHR) 分子名称: Transthyretin, chrysin 著者 Trivella, D.B.B, Polikarpov, I. 登録日 2012-01-21 公開日 2012-11-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180, 2012
4DHL	Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment MO07123 分子名称: 1,2-ETHANEDIOL, 2-(4-methylphenyl)-1,3-thiazole-4-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Feder, D, Clayton, D.J, Hussein, W.M, Schenk, G, McGeary, R, Guddat, L.W. 登録日 2012-01-29 公開日 2012-12-12 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem.Biol.Drug Des., 80, 2012
4EFU	Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid benzyl-methyl-amide 分子名称: Heat shock protein HSP 90-alpha, N-benzyl-6-hydroxy-N-methyl-3-(3-methylbenzyl)-1H-indazole-5-carboxamide, SULFATE ION 著者 Musil, D, Lehmann, M, Graedler, U, Buchstaller, H.-P. 登録日 2012-03-30 公開日 2012-06-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90 Bioorg.Med.Chem.Lett., 22, 2012
4EWA	Study on structure and function relationships in human Pirin with Fe ion 分子名称: FE (III) ION, Pirin 著者 Liu, F, Rehmani, I, Chen, L, Fu, R, Serrano, V, Wilson, D.W, Liu, A. 登録日 2012-04-26 公開日 2013-05-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Pirin is an iron-dependent redox regulator of NF-kappa B. Proc.Natl.Acad.Sci.USA, 110, 2013
4X6K	Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with Siastatin B 分子名称: (2S,3R,4S,5S)-2-(acetylamino)-5-carboxy-3,4-dihydroxypiperidinium, ACETYL GROUP, Anhydrosialidase 著者 Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N. 登録日 2014-12-08 公開日 2015-07-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat Commun, 6, 2015
4X4A	Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with 2,7-Anhydro-Neu5Ac 分子名称: 2-ACETYLAMINO-7-(1,2-DIHYDROXY-ETHYL)-3-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCTANE-5-CARBOXYLIC ACID, ACETYL GROUP, Anhydrosialidase, ... 著者 Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N. 登録日 2014-12-02 公開日 2015-07-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat Commun, 6, 2015
5EI3	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: Eukaryotic translation initiation factor 4 gamma, Eukaryotic translation initiation factor 4E, SULFATE ION, ... 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-10-29 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
1XNN	CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN T877A MUTANT COMPLEX WITH (3A-ALPHA-,4-ALPHA 7-ALPHA-,7A-ALPHA-)-3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE. 分子名称: Androgen receptor, REL-(3AR,4S,7R,7AS)-3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE 著者 Sack, J. 登録日 2004-10-05 公開日 2005-10-11 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists. Bioorg.Med.Chem.Lett., 15, 2005
8T9A	CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3 分子名称: DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, Melanoma-associated antigen 3 著者 Duda, D, Righetto, G, Li, Y, Loppnau, P, Seitova, A, Santhakumar, V, Halabelian, L, Yin, Y. 登録日 2023-06-23 公開日 2024-04-10 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3 To Be Published
4F18	Subatomic resolution structure of a high affinity periplasmic phosphate-binding protein (PfluDING) bound with arsenate at pH 8.5 分子名称: Putative alkaline phosphatase, hydrogen arsenate 著者 Elias, M, Wellner, A, Goldin, K, Chabriere, E, Tawfik, D.S. 登録日 2012-05-06 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.96 Å) 主引用文献 The molecular basis of phosphate discrimination in arsenate-rich environments. Nature, 491, 2012
5A31	Structure of the human APC-Cdh1-Hsl1-UbcH10 complex. 分子名称: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... 著者 Chang, L, Zhang, Z, Yang, J, Mclaughlin, S.H, Barford, D. 登録日 2015-05-26 公開日 2015-11-18 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Atomic Structure of the Apc/C and its Mechanism of Protein Ubiquitination. Nature, 522, 2015
2BZ8	N-terminal Sh3 domain of CIN85 bound to Cbl-b peptide 分子名称: SH3-DOMAIN KINASE BINDING PROTEIN 1, SIGNAL TRANSDUCTION PROTEIN CBL-B SH3-BINDING PROTEIN CBL-B, RING FINGER PROTEIN 56, ... 著者 Cardenes, N, Moncalian, G, Bravo, J. 登録日 2005-08-12 公開日 2005-10-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Cbl Promotes Clustering of Endocytic Adaptor Proteins Nat.Struct.Mol.Biol., 12, 2005
4EYY	Crystal Structure of the IcmR-IcmQ complex from Legionella pneumophila 分子名称: IcmQ, IcmR 著者 Farelli, J.D, Gumbart, J, Akey, I.V, Amyot, W, Hempstead, A.D, Head, J.F, McKnight, C.J, Isberg, R.R, Akey, C.W. 登録日 2012-05-02 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure, 21, 2013
4F19	Subatomic resolution structure of a high affinity periplasmic phosphate-binding protein (PfluDING) bound with arsenate at pH 4.5 分子名称: Putative alkaline phosphatase, hydrogen arsenate 著者 Elias, M, Wellner, A, Goldin, K, Chabriere, E, Tawfik, D.S. 登録日 2012-05-06 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.95 Å) 主引用文献 The molecular basis of phosphate discrimination in arsenate-rich environments. Nature, 491, 2012
5FHH	Structure of human Pif1 helicase domain residues 200-641 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase PIF1, TETRAFLUOROALUMINATE ION 著者 Zhou, X, Ren, W, Bharath, S.R, Song, H. 登録日 2015-12-22 公開日 2016-03-30 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep, 14, 2016
4BME	Crystal structure of the N terminal domain of human Galectin 8, F19Y mutant 分子名称: GALECTIN-8, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose 著者 Buzamet, E, Ruiz, F.M, Menendez, M, Romero, A, Gabius, H.J, Solis, D. 登録日 2013-05-07 公開日 2014-03-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Natural Single Amino Acid Polymorphism (F19Y) in Human Galectin-8: Detection of Structural Alterations and Increased Growth-Regulatory Activity on Tumor Cells. FEBS J., 281, 2014
4BP3	Crystal Structure of Plasmodium Falciparum Spermidine Synthase in Complex with DECARBOXYLATED S-ADENOSYLMETHIONINE5' AND 4- METHYLANILINE 分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 4-METHYLANILINE, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, ... 著者 Sprenger, J, Halander, J.C, Svensson, B, Al-Karadaghi, S, Persson, L. 登録日 2013-05-23 公開日 2014-06-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Three-Dimensional Structures of Plasmodium Falciparum Spermidine Synthase with Bound Inhibitors Suggest New Strategies for Drug Design Acta Crystallogr.,Sect.D, 71, 2015
5EKV	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-11-04 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.61 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
4CDT	Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-((3-Fluorophenethylamino)ethyl)quinolin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[2-[2-(3-fluorophenyl)ethylamino]ethyl]quinolin-2-amine, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2013-11-05 公開日 2014-02-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition. J.Med.Chem., 57, 2014
4F1U	Subatomic resolution structure of a high affinity periplasmic phosphate-binding protein (PfluDING) bound with phosphate at pH 4.5 分子名称: 1,2-ETHANEDIOL, HYDROGENPHOSPHATE ION, Putative alkaline phosphatase, ... 著者 Liebschner, D, Elias, M, Tawfik, D.S, Moniot, S, Fournier, B, Scott, K, Jelsch, C, Guillot, B, Lecomte, C, Chabriere, E. 登録日 2012-05-07 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.98 Å) 主引用文献 The molecular basis of phosphate discrimination in arsenate-rich environments. Nature, 491, 2012
4F1V	Subatomic resolution structure of a high affinity periplasmic phosphate-binding protein (PfluDING) bound with phosphate at pH 8.5 分子名称: HYDROGENPHOSPHATE ION, Putative alkaline phosphatase, SULFATE ION 著者 Liebschner, D, Elias, M, Tawfik, D.S, Moniot, S, Fournier, B, Scott, K, Jelsch, C, Guillot, B, Lecomte, C, Chabriere, E. 登録日 2012-05-07 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.88 Å) 主引用文献 The molecular basis of phosphate discrimination in arsenate-rich environments. Nature, 491, 2012
5EHC	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-10-28 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016

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